ENSMUSG00000037533


Mus musculus

Features
Gene ID: ENSMUSG00000037533
  
Biological name :Rapgef6
  
Synonyms : Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6
  
Possible biological names infered from orthology : AC008695.1 / Q8TEU7 / Rap guanine nucleotide exchange factor 6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 54522847
Gene end: 54699285
  
Corresponding Affymetrix probe sets: 10376163 (MoGene1.0st)   1427412_s_at (Mouse Genome 430 2.0 Array)   1434509_at (Mouse Genome 430 2.0 Array)   1438828_at (Mouse Genome 430 2.0 Array)   1443877_a_at (Mouse Genome 430 2.0 Array)   1443878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147135
Ensembl peptide - ENSMUSP00000114574
Ensembl peptide - ENSMUSP00000151509
Ensembl peptide - ENSMUSP00000092114
Ensembl peptide - ENSMUSP00000098766
Ensembl peptide - ENSMUSP00000099804
Ensembl peptide - ENSMUSP00000104522
Ensembl peptide - ENSMUSP00000104523
NCBI entrez gene - 192786     See in Manteia.
MGI - MGI:2384761
RefSeq - XM_017314348
RefSeq - NM_001252496
RefSeq - NM_001252497
RefSeq - NM_001252498
RefSeq - NM_175258
RefSeq - XM_006532560
RefSeq - XM_006532561
RefSeq - XM_006532562
RefSeq - XM_006532563
RefSeq - XM_006532564
RefSeq - XM_006532565
RefSeq - XM_006532566
RefSeq - XM_006532567
RefSeq - XM_006532568
RefSeq - NM_001252494
RefSeq Peptide - NP_001239425
RefSeq Peptide - NP_001239426
RefSeq Peptide - NP_001239427
RefSeq Peptide - NP_780467
RefSeq Peptide - NP_001239423
swissprot - Q5NCJ5
swissprot - A0A1W2P734
swissprot - F7ACB1
swissprot - Q5NCJ0
swissprot - B2RUJ6
swissprot - Q5NCJ1
swissprot - Q5NCJ2
swissprot - Q5NCJ4
Ensembl - ENSMUSG00000037533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef6ENSDARG00000010945Danio rerio
 ENSGALG00000029896Gallus gallus
 AC008695.1ENSG00000273217Homo sapiens
 Q8TEU7ENSG00000158987Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223260
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904415
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246913
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199212
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG000000273479
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG000000380208
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG000000301347
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG000000710427
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG000000203747
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG000000305897
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG000000898097
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG000000329466


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001478  PDZ domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0030033 microvillus assembly ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030139 endocytic vesicle ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017016 Ras GTPase binding ISO
 molecular_functionGO:0030742 GTP-dependent protein binding ISO
 molecular_functionGO:0070300 phosphatidic acid binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pstpip2Lupo/Pstpip2Lupo,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pstpip2Lupo/Pstpip2Lupo,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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