ENSMUSG00000071042


Mus musculus

Features
Gene ID: ENSMUSG00000071042
  
Biological name :Rasgrp3
  
Synonyms : Rasgrp3 / RAS, guanyl releasing protein 3
  
Possible biological names infered from orthology : Q8IV61
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E2
Gene start: 75435905
Gene end: 75529043
  
Corresponding Affymetrix probe sets: 10446965 (MoGene1.0st)   1438030_at (Mouse Genome 430 2.0 Array)   1438031_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092828
Ensembl peptide - ENSMUSP00000129393
NCBI entrez gene - 240168     See in Manteia.
MGI - MGI:3028579
RefSeq - XM_006524273
RefSeq - NM_001166493
RefSeq - NM_207246
RefSeq - XM_006524271
RefSeq - XM_006524272
RefSeq Peptide - NP_001159965
RefSeq Peptide - NP_997129
swissprot - Q6NZH9
Ensembl - ENSMUSG00000071042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp3ENSDARG00000077864Danio rerio
 RASGRP3ENSGALG00000010435Gallus gallus
 Q8IV61ENSG00000152689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG0000002734751
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG0000003294645
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG0000003058937
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223218
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753317
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246914
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904413
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG0000008980912
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013412
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199212
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG0000002037411
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG0000003802010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029645  Ras guanyl-releasing protein 1/3
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction






 

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