ENSG00000152689


Homo sapiens

Features
Gene ID: ENSG00000152689
  
Biological name :RASGRP3
  
Synonyms : Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p22.3
Gene start: 33436324
Gene end: 33564750
  
Corresponding Affymetrix probe sets: 205801_s_at (Human Genome U133 Plus 2.0 Array)   244526_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388139
Ensembl peptide - ENSP00000385886
Ensembl peptide - ENSP00000393866
Ensembl peptide - ENSP00000409593
Ensembl peptide - ENSP00000405648
Ensembl peptide - ENSP00000401974
Ensembl peptide - ENSP00000400602
Ensembl peptide - ENSP00000383917
Ensembl peptide - ENSP00000384192
NCBI entrez gene - 25780     See in Manteia.
OMIM - 609531
RefSeq - XM_017003763
RefSeq - NM_001139488
RefSeq - NM_001349978
RefSeq - NM_001349979
RefSeq - NM_001349981
RefSeq - NM_015376
RefSeq - NM_170672
RefSeq - XM_005264246
RefSeq - XM_011532746
RefSeq - XM_011532747
RefSeq - XM_011532748
RefSeq - XM_017003759
RefSeq - XM_017003760
RefSeq - XM_017003761
RefSeq - XM_017003762
RefSeq Peptide - NP_001336905
RefSeq Peptide - NP_001336907
RefSeq Peptide - NP_001336908
RefSeq Peptide - NP_001336909
RefSeq Peptide - NP_001336910
RefSeq Peptide - NP_056191
RefSeq Peptide - NP_733772
RefSeq Peptide - NP_001132960
RefSeq Peptide - NP_001336904
RefSeq Peptide - NP_001336906
swissprot - C9K0P4
swissprot - C9JWP0
swissprot - C9JSS2
swissprot - C9J9C9
swissprot - H7C352
swissprot - Q8IV61
swissprot - C9IYA5
Ensembl - ENSG00000152689
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp3ENSDARG00000077864Danio rerio
 RASGRP3ENSGALG00000010435Gallus gallus
 Rasgrp3ENSMUSG00000071042Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG0000017257553
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883146
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177738
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975618
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898717
AC008695.1ENSG0000027321717
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933714
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142813
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867012
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891512
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623711
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609011
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029645  Ras guanyl-releasing protein 1/3
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade NAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019992 diacylglycerol binding NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction






 

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