ENSG00000079337


Homo sapiens

Features
Gene ID: ENSG00000079337
  
Biological name :RAPGEF3
  
Synonyms : O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.11
Gene start: 47734367
Gene end: 47771040
  
Corresponding Affymetrix probe sets: 210051_at (Human Genome U133 Plus 2.0 Array)   215027_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449905
Ensembl peptide - ENSP00000448804
Ensembl peptide - ENSP00000449818
Ensembl peptide - ENSP00000373864
Ensembl peptide - ENSP00000378764
Ensembl peptide - ENSP00000384521
Ensembl peptide - ENSP00000395708
Ensembl peptide - ENSP00000446731
Ensembl peptide - ENSP00000447691
Ensembl peptide - ENSP00000448480
Ensembl peptide - ENSP00000448619
NCBI entrez gene - 10411     See in Manteia.
OMIM - 606057
RefSeq - XM_017018688
RefSeq - NM_001098531
RefSeq - NM_001098532
RefSeq - NM_006105
RefSeq - XM_005268571
RefSeq - XM_011537752
RefSeq - XM_011537755
RefSeq - XM_011537758
RefSeq Peptide - NP_001092001
RefSeq Peptide - NP_006096
RefSeq Peptide - NP_001092002
swissprot - F8W0N0
swissprot - H0YHS2
swissprot - H0YIP6
swissprot - F8VRX1
swissprot - O95398
swissprot - F8VVJ6
swissprot - F8VXK1
Ensembl - ENSG00000079337
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef3ENSDARG00000079291Danio rerio
 RAPGEF3ENSGALG00000043775Gallus gallus
 Q8VCC8ENSMUSG00000022469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142847
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623728
AC008695.1ENSG0000027321724
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898724
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975623
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835219
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177712
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG0000017257511
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891511
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609011
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG0000015268910
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867010
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0019933 cAMP-mediated signaling NAS
 biological_processGO:0030822 obsolete positive regulation of cAMP catabolic process NAS
 biological_processGO:0032486 Rap protein signal transduction IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034242 negative regulation of syncytium formation by plasma membrane fusion IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046827 positive regulation of protein export from nucleus IDA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0060143 positive regulation of syncytium formation by plasma membrane fusion IMP
 biological_processGO:0061028 establishment of endothelial barrier IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:1901985 positive regulation of protein acetylation IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction






 

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