ENSG00000198915


Homo sapiens

Features
Gene ID: ENSG00000198915
  
Biological name :RASGEF1A
  
Synonyms : Q8N9B8 / RASGEF1A / RasGEF domain family member 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q11.21
Gene start: 43194535
Gene end: 43266919
  
Corresponding Affymetrix probe sets: 230563_at (Human Genome U133 Plus 2.0 Array)   242917_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363579
Ensembl peptide - ENSP00000363583
Ensembl peptide - ENSP00000379154
Ensembl peptide - ENSP00000379155
NCBI entrez gene - 221002     See in Manteia.
OMIM - 614531
RefSeq - XM_011539500
RefSeq - NM_001282862
RefSeq - NM_145313
RefSeq - XM_005271809
RefSeq Peptide - NP_660356
RefSeq Peptide - NP_001269791
swissprot - Q8N9B8
swissprot - H7BYA3
Ensembl - ENSG00000198915
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGEF1AENSGALG00000002525Gallus gallus
 Rasgef1aENSMUSG00000030134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867058
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609052
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975624
AC008695.1ENSG0000027321723
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898723
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933721
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142820
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623720
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG0000017257519
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883117
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG0000015268917
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177716
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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