ENSG00000109756


Homo sapiens

Features
Gene ID: ENSG00000109756
  
Biological name :RAPGEF2
  
Synonyms : Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.1
Gene start: 159103013
Gene end: 159360174
  
Corresponding Affymetrix probe sets: 203096_s_at (Human Genome U133 Plus 2.0 Array)   203097_s_at (Human Genome U133 Plus 2.0 Array)   215987_at (Human Genome U133 Plus 2.0 Array)   215992_s_at (Human Genome U133 Plus 2.0 Array)   238176_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422707
Ensembl peptide - ENSP00000422361
Ensembl peptide - ENSP00000427334
Ensembl peptide - ENSP00000495906
Ensembl peptide - ENSP00000495298
Ensembl peptide - ENSP00000264431
Ensembl peptide - ENSP00000421083
Ensembl peptide - ENSP00000421602
Ensembl peptide - ENSP00000421624
Ensembl peptide - ENSP00000421740
Ensembl peptide - ENSP00000422098
NCBI entrez gene - 9693     See in Manteia.
OMIM - 609530
RefSeq - XM_017008859
RefSeq - XM_005263360
RefSeq - XM_005263361
RefSeq - XM_006714420
RefSeq - XM_006714421
RefSeq - XM_006714422
RefSeq - XM_011532425
RefSeq - XM_011532426
RefSeq - XM_011532427
RefSeq - XM_017008856
RefSeq - XM_017008857
RefSeq - XM_017008858
RefSeq - NM_001351726
RefSeq - NM_014247
RefSeq - XM_005263358
RefSeq - XM_005263359
RefSeq Peptide - NP_001338655
RefSeq Peptide - NP_055062
swissprot - H0Y8H7
swissprot - H0Y8N8
swissprot - H0Y8T6
swissprot - D6REY8
swissprot - H0YAJ8
swissprot - Q9Y4G8
swissprot - D6RAK0
swissprot - H0Y905
swissprot - D6RC78
Ensembl - ENSG00000109756
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef2ENSDARG00000005482Danio rerio
 RAPGEF2ENSGALG00000020249Gallus gallus
 Q8CHG7ENSMUSG00000062232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898764
AC008695.1ENSG0000027321763
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933714
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142814
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623712
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG000001725759
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG000001526898
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG000001083528
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG000001386708
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG000001989158
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG000001717778
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG000001460907
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG000000688317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001478  PDZ domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR030739  Rap guanine nucleotide exchange factor 2
 IPR036034  PDZ superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade NAS
 biological_processGO:0001568 blood vessel development ISS
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0019933 cAMP-mediated signaling NAS
 biological_processGO:0021591 ventricular system development ISS
 biological_processGO:0021884 forebrain neuron development ISS
 biological_processGO:0030033 microvillus assembly IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0031547 brain-derived neurotrophic factor receptor signaling pathway ISS
 biological_processGO:0032092 positive regulation of protein binding ISS
 biological_processGO:0032486 Rap protein signal transduction IMP
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0038180 nerve growth factor signaling pathway ISS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0048022 negative regulation of melanin biosynthetic process ISS
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IDA
 biological_processGO:0061028 establishment of endothelial barrier IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071321 cellular response to cGMP IDA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IDA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090557 establishment of endothelial intestinal barrier IMP
 biological_processGO:1901888 regulation of cell junction assembly IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus ISS
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IDA
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IDA
 biological_processGO:2001214 positive regulation of vasculogenesis ISS
 biological_processGO:2001224 positive regulation of neuron migration ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019992 diacylglycerol binding NAS
 molecular_functionGO:0030165 PDZ domain binding IDA
 molecular_functionGO:0030552 cAMP binding IDA
 molecular_functionGO:0031697 beta-1 adrenergic receptor binding IDA
 molecular_functionGO:0050699 WW domain binding IDA
 molecular_functionGO:0070300 phosphatidic acid binding IDA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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