ENSG00000136237


Homo sapiens

Features
Gene ID: ENSG00000136237
  
Biological name :RAPGEF5
  
Synonyms : Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p15.3
Gene start: 22118238
Gene end: 22357144
  
Corresponding Affymetrix probe sets: 1561269_at (Human Genome U133 Plus 2.0 Array)   1563882_a_at (Human Genome U133 Plus 2.0 Array)   204680_s_at (Human Genome U133 Plus 2.0 Array)   204681_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384044
Ensembl peptide - ENSP00000343656
Ensembl peptide - ENSP00000479340
Ensembl peptide - ENSP00000415664
Ensembl peptide - ENSP00000403956
Ensembl peptide - ENSP00000395729
Ensembl peptide - ENSP00000384870
NCBI entrez gene - 9771     See in Manteia.
OMIM - 609527
RefSeq - XM_017012837
RefSeq - NM_012294
RefSeq - XM_005249914
RefSeq - XM_005249916
RefSeq - XM_011515652
RefSeq Peptide - NP_036426
swissprot - F8WD32
swissprot - E9PGY3
swissprot - Q92565
swissprot - C9JHM4
swissprot - C9JBS6
swissprot - A8MQ07
swissprot - A0A0S2Z561
swissprot - A0A0S2Z5S1
Ensembl - ENSG00000136237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef5aENSDARG00000075271Danio rerio
 RAPGEF5ENSGALG00000034024Gallus gallus
 Q8C0Q9ENSMUSG00000041992Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142843
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933735
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835227
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975625
AC008695.1ENSG0000027321724
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898724
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891514
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867013
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609012
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG0000015268911
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177711
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG0000017257511
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction NAS
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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