ENSG00000158987


Homo sapiens

Features
Gene ID: ENSG00000158987
  
Biological name :RAPGEF6
  
Synonyms : Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 131423921
Gene end: 131635236
  
Corresponding Affymetrix probe sets: 1555247_a_at (Human Genome U133 Plus 2.0 Array)   219112_at (Human Genome U133 Plus 2.0 Array)   230078_at (Human Genome U133 Plus 2.0 Array)   239438_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425389
Ensembl peptide - ENSP00000487439
Ensembl peptide - ENSP00000427102
Ensembl peptide - ENSP00000426910
Ensembl peptide - ENSP00000426081
Ensembl peptide - ENSP00000425891
Ensembl peptide - ENSP00000425772
Ensembl peptide - ENSP00000296859
Ensembl peptide - ENSP00000311419
Ensembl peptide - ENSP00000421684
Ensembl peptide - ENSP00000424574
NCBI entrez gene - 51735     See in Manteia.
OMIM - 610499
RefSeq - NM_001164388
RefSeq - NM_001164389
RefSeq - NM_001164387
RefSeq - NM_016340
RefSeq - NM_001164386
RefSeq - NM_001164390
RefSeq Peptide - NP_001157858
RefSeq Peptide - NP_001157860
RefSeq Peptide - NP_001157861
RefSeq Peptide - NP_001157862
RefSeq Peptide - NP_057424
RefSeq Peptide - NP_001157859
swissprot - Q8TEU7
swissprot - D6RE77
swissprot - D6RD23
swissprot - D6RB02
swissprot - B7Z7Y1
swissprot - D6RIH0
Ensembl - ENSG00000158987
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef6ENSDARG00000010945Danio rerio
 ENSGALG00000029896Gallus gallus
 Rapgef6ENSMUSG00000037533Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC008695.1ENSG0000027321799
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975659
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142815
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933714
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623711
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG000001725759
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG000001526897
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG000001386707
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG000001989157
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG000001717777
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG000001083527
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG000000688316
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG000001460906


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001478  PDZ domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036034  PDZ superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction NAS
 biological_processGO:0030033 microvillus assembly IGI
 biological_processGO:0043087 regulation of GTPase activity NAS
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030139 endocytic vesicle IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IDA
 molecular_functionGO:0030742 GTP-dependent protein binding IDA
 molecular_functionGO:0070300 phosphatidic acid binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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