ENSG00000172575


Homo sapiens

Features
Gene ID: ENSG00000172575
  
Biological name :RASGRP1
  
Synonyms : O95267 / RASGRP1 / RAS guanyl releasing protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q14
Gene start: 38488103
Gene end: 38565575
  
Corresponding Affymetrix probe sets: 205590_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454164
Ensembl peptide - ENSP00000454005
Ensembl peptide - ENSP00000454053
Ensembl peptide - ENSP00000310244
Ensembl peptide - ENSP00000388540
Ensembl peptide - ENSP00000413105
Ensembl peptide - ENSP00000444762
Ensembl peptide - ENSP00000452721
Ensembl peptide - ENSP00000452859
Ensembl peptide - ENSP00000452892
Ensembl peptide - ENSP00000453583
Ensembl peptide - ENSP00000453729
Ensembl peptide - ENSP00000453905
NCBI entrez gene - 10125     See in Manteia.
OMIM - 603962
RefSeq - XM_017021860
RefSeq - NM_001128602
RefSeq - NM_001306086
RefSeq - NM_005739
RefSeq - XM_005254114
RefSeq - XM_011521151
RefSeq Peptide - NP_001293015
RefSeq Peptide - NP_005730
RefSeq Peptide - NP_001122074
swissprot - F5H514
swissprot - H0YKM0
swissprot - H0YKP8
swissprot - H0YMF3
swissprot - H0YMT0
swissprot - H0YNG8
swissprot - H0YN83
swissprot - H0YNK9
swissprot - O95267
Ensembl - ENSG00000172575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRP1ENSGALG00000009740Gallus gallus
 Q9Z1S3ENSMUSG00000027347Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG0000015268946
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177738
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883133
AC008695.1ENSG0000027321718
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975618
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898718
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867012
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933712
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891511
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142811
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609011
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623710
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG000001083529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029645  Ras guanyl-releasing protein 1/3
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032252 secretory granule localization IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032816 positive regulation of natural killer cell activation IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IMP
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0051259 protein complex oligomerization IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090630 activation of GTPase activity IMP
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding IMP
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IMP
 molecular_functionGO:0008289 lipid binding TAS
 molecular_functionGO:0019992 diacylglycerol binding IMP
 molecular_functionGO:0031210 phosphatidylcholine binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Activation of RAS in B cells
FCERI mediated NF-kB activation
Integrin alphaIIb beta3 signaling
Rap1 signalling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr