ENSGALG00000009740


Gallus gallus

Features
Gene ID: ENSGALG00000009740
  
Biological name :RASGRP1
  
Synonyms : RASGRP1 / RAS guanyl releasing protein 1
  
Possible biological names infered from orthology : O95267 / Q9Z1S3
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 30675311
Gene end: 30714811
  
Corresponding Affymetrix probe sets: GgaAffx.6112.1.S1_at (Chicken Array)   GgaAffx.6114.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043864
Ensembl peptide - ENSGALP00000061452
Ensembl peptide - ENSGALP00000046639
Ensembl peptide - ENSGALP00000031964
NCBI entrez gene - 423290     See in Manteia.
RefSeq - XM_004941732
RefSeq - XM_004941735
swissprot - E1C758
swissprot - A0A1D5P1U7
swissprot - Q5F3V4
Ensembl - ENSGALG00000009740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O95267ENSG00000172575Homo sapiens
 Q9Z1S3ENSMUSG00000027347Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*ENSGALG0000001043548
RAPGEF2 / Rap guanine nucleotide exchange factor 2 / Q8CHG7* / Q9Y4G8*ENSGALG0000002024916
Q8TEU7* / RAPGEF6* / AC008695.1* / Rap guanine nucleotide exchange factor 6* / Rap guanine nucleotide exchange factor (GEF) 6*ENSGALG0000002989616
RAPGEF3 / Rap guanine nucleotide exchange factor 3 / O95398* / Q8VCC8* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA.*ENSGALG0000004377510
RAPGEFL1 / Rap guanine nucleotide exchange factor like 1 / Q68EF8* / Q9UHV5*ENSGALG0000003569010
RASGEF1C / RasGEF domain family member 1C / Q8N431* / Q9D300* / Ras-GEF domain-containing family member 1C *ENSGALG0000000607610
RAPGEF5 / Rap guanine nucleotide exchange factor 5 / Q8C0Q9* / Q92565*ENSGALG000000340249
RAPGEF4 / Rap guanine nucleotide exchange factor 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor (GEF) 4*ENSGALG000000436949
RASGEF1A / RasGEF domain family member 1A / Q8N9B8*ENSGALG000000025257
Q0VAM2* / Q8JZL7* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSGALG000000109032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0032252 secretory granule localization IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032816 positive regulation of natural killer cell activation IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019992 diacylglycerol binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
Integrin alphaIIb beta3 signaling
Rap1 signalling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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