ENSGALG00000043775


Gallus gallus

Features
Gene ID: ENSGALG00000043775
  
Biological name :RAPGEF3
  
Synonyms : RAPGEF3 / Rap guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology : Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398 / Q8VCC8
  
Species: Gallus gallus
  
Chr. number: 33
Strand: 1
Band:
Gene start: 464899
Gene end: 477972
  
Corresponding Affymetrix probe sets: Gga.8373.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057387
NCBI entrez gene - 426888     See in Manteia.
RefSeq - XM_015300251
swissprot - A0A1D5PWQ0
Ensembl - ENSGALG00000043775
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef3ENSDARG00000079291Danio rerio
 O95398ENSG00000079337Homo sapiens
 Q8VCC8ENSMUSG00000022469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAPGEF4 / Rap guanine nucleotide exchange factor 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor (GEF) 4*ENSGALG0000004369446
Q8TEU7* / RAPGEF6* / AC008695.1* / Rap guanine nucleotide exchange factor 6* / Rap guanine nucleotide exchange factor (GEF) 6*ENSGALG0000002989622
RAPGEF5 / Rap guanine nucleotide exchange factor 5 / Q8C0Q9* / Q92565*ENSGALG0000003402421
RAPGEF2 / Rap guanine nucleotide exchange factor 2 / Q8CHG7* / Q9Y4G8*ENSGALG0000002024921
RAPGEFL1 / Rap guanine nucleotide exchange factor like 1 / Q68EF8* / Q9UHV5*ENSGALG0000003569018
RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*ENSGALG0000001043510
RASGEF1C / RasGEF domain family member 1C / Q8N431* / Q9D300* / Ras-GEF domain-containing family member 1C *ENSGALG0000000607610
RASGRP1 / RAS guanyl releasing protein 1 / O95267* / Q9Z1S3*ENSGALG000000097407
RASGEF1A / RasGEF domain family member 1A / Q8N9B8*ENSGALG000000025257
Q0VAM2* / Q8JZL7* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSGALG000000109033


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034242 negative regulation of syncytium formation by plasma membrane fusion IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0060143 positive regulation of syncytium formation by plasma membrane fusion IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:1901985 positive regulation of protein acetylation IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction






 

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