ENSGALG00000001476


Gallus gallus

Features
Gene ID: ENSGALG00000001476
  
Biological name :RAP1A
  
Synonyms : RAP1A / RAP1A, member of RAS oncogene family
  
Possible biological names infered from orthology : P62834 / P62835 / RAS-related protein 1a
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 3234994
Gene end: 3256864
  
Corresponding Affymetrix probe sets: Gga.14257.1.S1_at (Chicken Array)   Gga.19788.1.S1_at (Chicken Array)   Gga.4383.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002236
NCBI entrez gene - 419867     See in Manteia.
RefSeq - XM_417994
swissprot - F1NSA8
Ensembl - ENSGALG00000001476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAP1AENSG00000116473Homo sapiens
 Rap1aENSMUSG00000068798Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*ENSGALG0000000992795
RAP2CENSGALG0000000606161
RAP2A / RAP2A, member of RAS oncogene family / P10114* / Q80ZJ1* / Ras-related protein Rap-2a *ENSGALG0000001688961
RAP2B / RAP2B, member of RAS oncogene family / P61225* / P61226*ENSGALG0000004255361
RIT1 / Ras like without CAAX 1 / P70426* / Q92963* / GTP-binding protein Rit1 *ENSGALG0000001464749
RIT2 / Ras like without CAAX 2 / P70425* / Q99578* / GTP-binding protein Rit2 *ENSGALG0000003335349
DIRAS2 / DIRAS family GTPase 2 / Q5PR73* / Q96HU8* / GTP-binding protein Di-Ras2 *ENSGALG0000000532343
DIRAS1 / DIRAS family GTPase 1 / O95057* / Q91Z61* / GTP-binding protein Di-Ras1 *ENSGALG0000002695541
RASL10A / RAS-like, family 10, member A ENSGALG0000002155240
RASD2 / RASD family member 2 / P63032* / Q96D21* / GTP-binding protein Rhes *ENSGALG0000001254239
RASD1 / ras related dexamethasone induced 1 / O35626* / Q9Y272* / Dexamethasone-induced Ras-related protein 1 *ENSGALG0000000486037
RASL10B / RAS like family 10 member B / Q5SSG5* / Q96S79* / Ras-like protein family member 10B *ENSGALG0000000208630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:1901888 regulation of cell junction assembly IEA
 biological_processGO:2000301 negative regulation of synaptic vesicle exocytosis IEA
 biological_processGO:2001214 positive regulation of vasculogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
ARMS-mediated activation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
MET activates RAP1 and RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex / reaction
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / reaction / complex
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / reaction
 ENSGALG00000014701 RAP1GAP1 / RAP1 GTPase activating protein / P47736* / A2ALS5* / RAP1GAP* / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA.*  / reaction
 ENSGALG00000033885 RAP1GAP2 / rap1 GTPase-activating protein 2 / Q5SVL6* / Q684P5*  / reaction
 ENSGALG00000043775 RAPGEF3 / Rap guanine nucleotide exchange factor 3 / O95398* / Q8VCC8* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA.*  / reaction






 

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