ENSGALG00000009268


Gallus gallus

Features
Gene ID: ENSGALG00000009268
  
Biological name :FGG
  
Synonyms : FGG / fibrinogen gamma chain
  
Possible biological names infered from orthology : P02679 / Q8VCM7
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 20496742
Gene end: 20501963
  
Corresponding Affymetrix probe sets: Gga.1165.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015063
Ensembl peptide - ENSGALP00000063703
Ensembl peptide - ENSGALP00000063013
Ensembl peptide - ENSGALP00000060597
NCBI entrez gene - 395837     See in Manteia.
RefSeq - NM_204989
RefSeq Peptide - NP_990320
swissprot - E1BV78
swissprot - A0A1L1RVZ7
swissprot - A0A1L1RP77
Ensembl - ENSGALG00000009268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fggENSDARG00000037281Danio rerio
 FGGENSG00000171557Homo sapiens
 FggENSMUSG00000033860Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGA / fibrinogen alpha chain isoform 1 precursor / E9PV24* / P02671* / fibrinogen alpha chain* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSGALG0000000926630
FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*ENSGALG0000000926229
FGL1 / fibrinogen like 1 / Q08830*ENSGALG0000001360628
TNR / tenascin-R precursor / Q8BYI9* / Q92752* / tenascin R*ENSGALG0000000452626
TNC / tenascin C / P24821* / Q80YX1*ENSGALG0000003999026
TNN / tenascin N / Q80Z71* / Q9UQP3*ENSGALG0000000453825
ANGPTL3 / angiopoietin-related protein 3 precursor / Q9R182* / Q9Y5C1* / angiopoietin like 3* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSGALG0000001097824
ENSGALG0000001702924
ANGPTL4 / angiopoietin like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSGALG0000000061924
ANGPTL5 / Q86XS5* / angiopoietin like 5*ENSGALG0000001719123
TNXB* / P22105* / tenascin XB*ENSGALG0000004103120
ENSGALG0000004523818
ENSGALG0000002752017
ENSGALG0000003331417
ENSGALG0000004281917
ANGPT1L / angiopoietin-related protein 1-like precursor ENSGALG0000004150216
FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*ENSGALG0000000357816
ENSGALG0000004648216
ENSGALG0000004183316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0009306 protein secretion IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IEA
 biological_processGO:0090277 positive regulation of peptide hormone secretion IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / complex / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction






 

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