ENSGALG00000008332


Gallus gallus

Features
Gene ID: ENSGALG00000008332
  
Biological name :F2
  
Synonyms : F2 / prothrombin precursor
  
Possible biological names infered from orthology : coagulation factor II, thrombin / P00734 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 23437157
Gene end: 23447162
  
Corresponding Affymetrix probe sets: Gga.4117.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062682
Ensembl peptide - ENSGALP00000013544
NCBI entrez gene - 395306     See in Manteia.
RefSeq - NM_204605
RefSeq Peptide - NP_989936
swissprot - F1NXV6
swissprot - A0A1L1RV31
Ensembl - ENSGALG00000008332
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2ENSDARG00000036041Danio rerio
 F2ENSG00000180210Homo sapiens
 F2ENSMUSG00000027249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSGALG0000000429328
LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSGALG0000002888625
HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSGALG0000003397423
MST1 / hepatocyte growth factor-like protein precursor / P26928* / macrophage stimulating 1* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSGALG0000000272222
HGFAC / HGF activator / Q04756* / Q9R098* / hepatocyte growth factor activator*ENSGALG0000001562321
PLAT / plasminogen activator, tissue type / P00750* / P11214* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B*ENSGALG0000000370920
HABP2 / hyaluronan-binding protein 2 preproprotein / Q14520* / hyaluronan binding protein 2* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSGALG0000000890519
PLAU / plasminogen activator, urokinase / P00749* / P06869*ENSGALG0000000508617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003966  Prothrombin/thrombin
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR018992  Thrombin light chain
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0048712 negative regulation of astrocyte differentiation IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051838 cytolysis by host of symbiont cells IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 biological_processGO:0070945 neutrophil mediated killing of gram-negative bacterium IEA
 biological_processGO:0090218 positive regulation of lipid kinase activity IEA
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070053 thrombospondin receptor activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction
 ENSGALG00000004591 SERPINC1 / Gallus gallus serpin family C member 1 (SERPINC1), mRNA. / P32261* / P01008* / serpin family C member 1* / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1*  / complex / reaction
 ENSGALG00000023379 F2RL2 / coagulation factor II thrombin receptor like 2 / O00254* / O08675* / Proteinase-activated receptor 3 *  / reaction / complex
 ENSGALG00000014984 F2RL1 / F2R like trypsin receptor 1 / P55085* / P55086* / Proteinase-activated receptor 2 *  / complex / reaction
 ENSGALG00000037940 IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*  / reaction
 ENSGALG00000045125 GP5 / glycoprotein V platelet / P40197*  / reaction
 ENSGALG00000006547 PROCR / protein C receptor / Q64695* / Q9UNN8* / protein C receptor, endothelial*  / reaction
 ENSGALG00000005077 F8 / coagulation factor VIII / P00451* / Q06194*  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / complex
 ENSGALG00000021529 GP1BB / glycoprotein Ib platelet beta subunit / P13224* / P56400* / glycoprotein Ib, beta polypeptide*  / reaction
 ENSGALG00000001780 PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...  / reaction
 ENSGALG00000001565 C5 / complement C5 / Hc* / P01031* / P06684* / hemolytic complement*  / reaction
 ENSGALG00000039239 SERPIND1 / serpin family D member 1 / P05546* / P49182* / serine (or cysteine) peptidase inhibitor, clade D, member 1*  / reaction / complex
 ENSGALG00000035282 IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction
 ENSGALG00000012755 IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*  / reaction
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction
 ENSGALG00000005135 SERPINE2 / serpin family E member 2 / P07093* / Q07235* / serine (or cysteine) peptidase inhibitor, clade E, member 2*  / complex / reaction
 ENSGALG00000026677 F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*  / reaction
 ENSGALG00000044442 THBD / thrombomodulin / P07204* / P15306*  / complex / reaction






 

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