ENSGALG00000001780


Gallus gallus

Features
Gene ID: ENSGALG00000001780
  
Biological name :PROC
  
Synonyms : PROC / vitamin K-dependent protein C precursor
  
Possible biological names infered from orthology : P04070 / P33587 / protein C, inactivator of coagulation factors Va and VIIIa / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 1263547
Gene end: 1272258
  
Corresponding Affymetrix probe sets: Gga.5131.1.S1_at (Chicken Array)   GgaAffx.25147.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002742
NCBI entrez gene - 395085     See in Manteia.
RefSeq - NM_204441
RefSeq - XM_015276809
RefSeq - XM_015276810
RefSeq Peptide - NP_989772
swissprot - F1NGY6
Ensembl - ENSGALG00000001780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 procaENSDARG00000093079Danio rerio
 procaENSDARG00000038258Danio rerio
 PROCENSG00000115718Homo sapiens
 ProcENSMUSG00000024386Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*ENSGALG0000002667740
F7 / coagulation factor VII precursor / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSGALG0000001683340
F9 / coagulation factor IX precursor / P00740* / P16294* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSGALG0000000651339
ENSGALG0000004562236
PROZ / protein Z, vitamin K dependent plasma glycoprotein / P22891* / Q9CQW3*ENSGALG0000001683232
MASP1 / mannan-binding lectin serine protease 1 precursor / P48740* / P98064* / mannan binding lectin serine peptidase 1* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), t...ENSGALG0000000741930
MASP2 / mannan-binding lectin serine protease 2 precursor / O00187* / Q91WP0* / mannan binding lectin serine peptidase 2* / Mannan-binding lectin serine protease 2 Mannan-binding lectin se...ENSGALG0000000301629
C1S / complement C1s subcomponent precursor / C1s1* / C1s2* / Q8CFG8* / P09871* / complement C1s* / complement component 1, s subcomponent 1* / complement component 1, s subcomponent 2*ENSGALG0000001460327
C1R* / C1ra* / C1rb* / C1RL* / Q9NZP8* / P00736* / Q3UZ09* / Q8CFG9* / Q8CG16* / complement C1r* / complement C1r subcomponent like* / Complement C1r subcomponent-like protein * / Complemen...ENSGALG0000001465926
PAMR1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSGALG0000000788623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012224  Peptidase S1A, coagulation factor VII/IX/X/C/Z
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044537 regulation of circulating fibrinogen levels IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050819 negative regulation of coagulation IEA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005077 F8 / coagulation factor VIII / P00451* / Q06194*  / reaction
 ENSGALG00000001780 PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...  / complex
 ENSGALG00000006547 PROCR / protein C receptor / Q64695* / Q9UNN8* / protein C receptor, endothelial*  / reaction / complex
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction
 ENSGALG00000015409 PROS1 / protein S / P07225* / Q08761* / protein S (alpha)*  / complex / reaction






 

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