ENSMUSG00000024386


Mus musculus

Features
Gene ID: ENSMUSG00000024386
  
Biological name :Proc
  
Synonyms : P33587 / Proc / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide
  
Possible biological names infered from orthology : P04070 / protein C, inactivator of coagulation factors Va and VIIIa
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 32123129
Gene end: 32139570
  
Corresponding Affymetrix probe sets: 10458016 (MoGene1.0st)   1418845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132226
NCBI entrez gene - 19123     See in Manteia.
MGI - MGI:97771
RefSeq - NM_001313938
RefSeq - NM_008934
RefSeq - XM_011246857
RefSeq - NM_001042767
RefSeq - NM_001042768
RefSeq - XM_006525721
RefSeq - XM_006525722
RefSeq Peptide - NP_032960
RefSeq Peptide - NP_001036232
RefSeq Peptide - NP_001036233
RefSeq Peptide - NP_001300867
swissprot - P33587
Ensembl - ENSMUSG00000024386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 procaENSDARG00000093079Danio rerio
 procaENSDARG00000038258Danio rerio
 PROCENSGALG00000001780Gallus gallus
 PROCENSG00000115718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144437
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*ENSMUSG0000003144337
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*ENSMUSG0000003113835
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897929
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000009847028
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000005517228
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288728
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144527
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718824
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852124
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934324
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852722
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*ENSMUSG0000003172215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR012224  Peptidase S1A, coagulation factor VII/IX/X/C/Z
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0030195 negative regulation of blood coagulation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044537 regulation of circulating fibrinogen levels IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050819 negative regulation of coagulation IEA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001179 thicker alveolar septa 
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009275 bruising "an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: F11tm1Gjb/F11tm1Gjb,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041550 P70458 / Serpina5 / serine (or cysteine) peptidase inhibitor, clade A, member 5 / P05154* / serpin family A member 5*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000027611 Procr / Q64695 / protein C receptor, endothelial / Q9UNN8* / protein C receptor*  / complex / reaction
 ENSMUSG00000053460 Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / complex
 ENSMUSG00000022912 Pros1 / Q08761 / protein S (alpha) / P07225* / protein S*  / reaction / complex
 ENSMUSG00000026579 F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*  / reaction
 ENSMUSG00000031196 F8 / Q06194 / Coagulation factor VIII / P00451*  / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / reaction / complex






 

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