Manteia

ENSMUSG00000028979

Mus musculus

Features

Gene ID:	ENSMUSG00000028979

Biological name :	Masp2

Synonyms :	Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / Masp2 / Q91WP0

Possible biological names infered from orthology :	mannan binding lectin serine peptidase 2 / O00187

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	E2
Gene start:	148602554
Gene end:	148615499

Corresponding Affymetrix probe sets:	10510399 (MoGene1.0st) 1420524_a_at (Mouse Genome 430 2.0 Array) 1451759_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000049729 Ensembl peptide - ENSMUSP00000101326 NCBI entrez gene - 17175 See in Manteia. MGI - MGI:1330832 RefSeq - XM_011250202 RefSeq - NM_001003893 RefSeq - NM_010767 RefSeq Peptide - NP_034897 RefSeq Peptide - NP_001003893 swissprot - Q91WP0 Ensembl - ENSMUSG00000028979

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
masp2	ENSDARG00000007988	Danio rerio
MASP2	ENSGALG00000003016	Gallus gallus
MASP2	ENSG00000009724	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*	ENSMUSG00000022887	42
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000055172	41
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000098470	41
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*	ENSMUSG00000079343	39
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*	ENSMUSG00000038521	38
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*	ENSMUSG00000027188	21
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*	ENSMUSG00000038527	21
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...	ENSMUSG00000024386	19
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*	ENSMUSG00000031138	18
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*	ENSMUSG00000031443	17
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*	ENSMUSG00000031444	17
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*	ENSMUSG00000031722	15
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*	ENSMUSG00000031445	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000436	Sushi/SCR/CCP domain
IPR000742	EGF-like domain
IPR000859	CUB domain
IPR001254	Serine proteases, trypsin domain
IPR001314	Peptidase S1A, chymotrypsin family
IPR001881	EGF-like calcium-binding domain
IPR009003	Peptidase S1, PA clan
IPR013032	EGF-like, conserved site
IPR018097	EGF-like calcium-binding, conserved site
IPR033116	Serine proteases, trypsin family, serine active site
IPR035914	Spermadhesin, CUB domain superfamily
IPR035976	Sushi/SCR/CCP superfamily
IPR037571	Mannan-binding lectin-associated serine peptidase 2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001867	complement activation, lectin pathway	ISO
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006958	complement activation, classical pathway	IEA
biological_process	GO:0045087	innate immune response	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IBA
molecular_function	GO:0001855	complement component C4b binding	IEA
molecular_function	GO:0004252	serine-type endopeptidase activity	IBA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008233	peptidase activity	ISO
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048306	calcium-dependent protein binding	IEA

Pathways (from Reactome)

Pathway description

Lectin pathway of complement activation

Initial triggering of complement

Ficolins bind to repetitive carbohydrate structures on the target cell surface

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002471	abnormal complement cascade	"impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trp53^tm1Ldo/Trp53⁺ Genetic Background: B6.129S7-Trp53^tm1Ldo
MP:0003038	decreased infarction size	"decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Cep290^tm1.1Jgg/Cep290^tm1.1Jgg Genetic Background: involves: 129
MP:0005166	decreased susceptiblity to injury	"less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cep290^tm1.1Jgg/Cep290^tm1.1Jgg Genetic Background: involves: 129
MP:0009062	impaired lectin complement pathway	"abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cep290^tm1.1Jgg/Cep290^tm1.1Jgg Genetic Background: involves: 129

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026835	Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*	/ complex
ENSMUSG00000024863	Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*	/ complex
ENSMUSG00000073418	C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...	/ reaction
ENSMUSG00000038591	Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*	/ complex
ENSMUSG00000028979	Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...	/ complex
ENSMUSG00000036655	Colec11 / collectin subfamily member 11 / Q9BWP8*	/ complex
ENSMUSG00000024371	C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*	/ reaction
ENSMUSG00000022887	Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr