ENSMUSG00000024863


Mus musculus

Features
Gene ID: ENSMUSG00000024863
  
Biological name :Mbl2
  
Synonyms : mannose-binding lectin (protein C) 2 / Mbl2 / P41317
  
Possible biological names infered from orthology : mannose binding lectin 2 / P11226
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 30232928
Gene end: 30239685
  
Corresponding Affymetrix probe sets: 10462473 (MoGene1.0st)   1418787_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025797
NCBI entrez gene - 17195     See in Manteia.
MGI - MGI:96924
RefSeq - XM_006526730
RefSeq - NM_010776
RefSeq Peptide - NP_034906
swissprot - P41317
swissprot - Q3UEK1
Ensembl - ENSMUSG00000024863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbl1ENSDARG00000068221Danio rerio
 hbl2ENSDARG00000094681Danio rerio
 hbl4ENSDARG00000054202Danio rerio
 mbl2ENSDARG00000068220Danio rerio
 MBL2ENSGALG00000002507Gallus gallus
 MBL2ENSG00000165471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbl1 / P39039 / Mannose-binding protein A ENSMUSG0000003778052
Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*ENSMUSG0000002179541
Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*ENSMUSG0000002178936
Colec11 / collectin subfamily member 11 / Q9BWP8*ENSMUSG0000003665526
Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*ENSMUSG0000003859126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR008160  Collagen triple helix repeat
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR037570  Mannose-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0048525 negative regulation of viral process IEA
 biological_processGO:0050766 positive regulation of phagocytosis IGI
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051873 killing by host of symbiont cells IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005537 mannose binding IBA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0008552 abnormal circulating tumor necrosis factor level "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0008595 abnormal circulating interleukin-6 level "anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction
 ENSMUSG00000022887 Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*  / complex
 ENSMUSG00000024863 Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*  / complex
 ENSMUSG00000028979 Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...  / complex
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction






 

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