Manteia

ENSMUSG00000022887

Mus musculus

Features

Gene ID:	ENSMUSG00000022887

Biological name :	Masp1

Synonyms :	Masp1 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P98064

Possible biological names infered from orthology :	mannan binding lectin serine peptidase 1 / P48740

Species:	Mus musculus

Chr. number:	16
Strand:	-1
Band:	B1
Gene start:	23449417
Gene end:	23520815

Corresponding Affymetrix probe sets:	10438708 (MoGene1.0st) 1419677_at (Mouse Genome 430 2.0 Array) 1425985_s_at (Mouse Genome 430 2.0 Array) 1438602_s_at (Mouse Genome 430 2.0 Array) 1438603_x_at (Mouse Genome 430 2.0 Array) 1455346_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000087327 Ensembl peptide - ENSMUSP00000155343 Ensembl peptide - ENSMUSP00000155665 NCBI entrez gene - 17174 See in Manteia. MGI - MGI:88492 RefSeq - XM_006521829 RefSeq - NM_001359083 RefSeq - NM_008555 RefSeq - XM_006521828 RefSeq Peptide - NP_001346012 RefSeq Peptide - NP_032581 swissprot - P98064 Ensembl - ENSMUSG00000022887

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
masp1	ENSDARG00000068726	Danio rerio
MASP1	ENSGALG00000007419	Gallus gallus
MASP1	ENSG00000127241	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...	ENSMUSG00000028979	41
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000098470	37
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000055172	37
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*	ENSMUSG00000079343	36
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*	ENSMUSG00000038521	36
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*	ENSMUSG00000027188	20
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*	ENSMUSG00000031138	18
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*	ENSMUSG00000038527	18
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*	ENSMUSG00000031443	18
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...	ENSMUSG00000024386	18
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*	ENSMUSG00000031444	17
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*	ENSMUSG00000031722	14
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*	ENSMUSG00000031445	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000436	Sushi/SCR/CCP domain
IPR000859	CUB domain
IPR001254	Serine proteases, trypsin domain
IPR001314	Peptidase S1A, chymotrypsin family
IPR001881	EGF-like calcium-binding domain
IPR009003	Peptidase S1, PA clan
IPR013032	EGF-like, conserved site
IPR018097	EGF-like calcium-binding, conserved site
IPR018114	Serine proteases, trypsin family, histidine active site
IPR033116	Serine proteases, trypsin family, serine active site
IPR035914	Spermadhesin, CUB domain superfamily
IPR035976	Sushi/SCR/CCP superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001867	complement activation, lectin pathway	IMP
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0045087	innate immune response	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0004252	serine-type endopeptidase activity	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048306	calcium-dependent protein binding	IEA

Pathways (from Reactome)

Pathway description

Lectin pathway of complement activation

Initial triggering of complement

Ficolins bind to repetitive carbohydrate structures on the target cell surface

Scavenging by Class A Receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Vdr^tm1Mbd/Vdr⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002472	impaired complement alternative pathway	"abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Vdr^tm1Mbd/Vdr⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vdr^tm1Mbd/Vdr⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0009062	impaired lectin complement pathway	"abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vdr^tm1Mbd/Vdr⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026835	Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*	/ complex
ENSMUSG00000024863	Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*	/ complex
ENSMUSG00000024371	C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*	/ reaction
ENSMUSG00000073418	C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...	/ reaction
ENSMUSG00000022887	Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*	/ complex
ENSMUSG00000028979	Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...	/ complex
ENSMUSG00000038591	Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*	/ complex
ENSMUSG00000036655	Colec11 / collectin subfamily member 11 / Q9BWP8*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr