ENSMUSG00000055172


Mus musculus

Features
Gene ID: ENSMUSG00000055172
  
Biological name :C1ra
  
Synonyms : C1ra / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / Q8CG16
  
Possible biological names infered from orthology : C1R / complement C1r / P00736
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 124512405
Gene end: 124523443
  
Corresponding Affymetrix probe sets: 10541678 (MoGene1.0st)   10541683 (MoGene1.0st)   1417009_at (Mouse Genome 430 2.0 Array)   1456437_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063707
NCBI entrez gene - 50909     See in Manteia.
MGI - MGI:1355313
RefSeq - NM_023143
RefSeq Peptide - NP_075632
swissprot - Q8CG16
Ensembl - ENSMUSG00000055172
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000014659Gallus gallus
 C1RENSG00000159403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000009847096
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897940
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288737
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934336
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852136
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852732
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718820
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*ENSMUSG0000003113819
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144419
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...ENSMUSG0000002438618
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*ENSMUSG0000003144317
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*ENSMUSG0000003172215
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035707  Complement subcomponent C1r
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023224 P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*  / complex / reaction
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / complex
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / complex
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / complex
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / complex
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / complex
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction






 

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