ENSMUSG00000023224


Mus musculus

Features
Gene ID: ENSMUSG00000023224
  
Biological name :Serping1
  
Synonyms : P97290 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / Serping1
  
Possible biological names infered from orthology : P05155 / serpin family G member 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84765387
Gene end: 84775444
  
Corresponding Affymetrix probe sets: 10484463 (MoGene1.0st)   1416625_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107268
Ensembl peptide - ENSMUSP00000023994
NCBI entrez gene - 12258     See in Manteia.
MGI - MGI:894696
RefSeq - NM_009776
RefSeq - XM_006498623
RefSeq Peptide - NP_033906
swissprot - A2ATR8
swissprot - P97290
Ensembl - ENSMUSG00000023224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serping1ENSDARG00000058053Danio rerio
 SERPING1ENSGALG00000007381Gallus gallus
 P05155ENSG00000149131Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61247 / Serpinf2 / serine (or cysteine) peptidase inhibitor, clade F, member 2 / P08697* / serpin family F member 2*ENSMUSG0000003822423
P97298 / Serpinf1 / Pigment epithelium-derived factor / P36955* / serpin family F member 1*ENSMUSG0000000075319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015553  Plasma protease C1 inhibitor
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001869 negative regulation of complement activation, lectin pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045916 negative regulation of complement activation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serping1Gt1Aed/Serping1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

Allelic Composition: Serping1Gt1Aed/Serping1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / reaction / complex
 ENSMUSG00000023224 P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*  / complex / reaction
 ENSMUSG00000021492 F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*  / reaction / complex
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / reaction / complex
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / reaction / complex
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / complex / reaction
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / complex / reaction
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / complex / reaction
 ENSMUSG00000109764 Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*  / complex / reaction
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / reaction / complex






 

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