ENSMUSG00000000753


Mus musculus

Features
Gene ID: ENSMUSG00000000753
  
Biological name :Serpinf1
  
Synonyms : P97298 / Pigment epithelium-derived factor / Serpinf1
  
Possible biological names infered from orthology : P36955 / serpin family F member 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75409769
Gene end: 75422701
  
Corresponding Affymetrix probe sets: 10388430 (MoGene1.0st)   1416168_at (Mouse Genome 430 2.0 Array)   1453724_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121180
Ensembl peptide - ENSMUSP00000133230
Ensembl peptide - ENSMUSP00000131531
Ensembl peptide - ENSMUSP00000131043
Ensembl peptide - ENSMUSP00000126807
Ensembl peptide - ENSMUSP00000000769
Ensembl peptide - ENSMUSP00000114761
NCBI entrez gene - 20317     See in Manteia.
MGI - MGI:108080
RefSeq - NM_011340
RefSeq Peptide - NP_035470
swissprot - B7ZC25
swissprot - F6S1M4
swissprot - P97298
swissprot - E9PZX2
swissprot - Q5ND37
swissprot - E9PXR9
swissprot - E9PWS2
Ensembl - ENSMUSG00000000753
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinf1ENSDARG00000069048Danio rerio
 SERPINF1ENSGALG00000003015Gallus gallus
 P36955ENSG00000132386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61247 / Serpinf2 / serine (or cysteine) peptidase inhibitor, clade F, member 2 / P08697* / serpin family F member 2*ENSMUSG0000003822428
P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*ENSMUSG0000002322424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033832  Pigment epithelium derived factor
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007614 short-term memory IEA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050769 positive regulation of neurogenesis ISS
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0071279 cellular response to cobalt ion IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baz1bMommeD10/Baz1b+
Genetic Background: involves: FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serpinf1tm1Craw/Serpinf1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serpinf1tm1Craw/Serpinf1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serpinf1tm1Sjwi/Serpinf1tm1Sjwi
Genetic Background: involves: C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0003337 acinar hyperplasia "increased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0003450 enlarged pancreas "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0010929 increased osteoid thickness "increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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