ENSMUSG00000038224


Mus musculus

Features
Gene ID: ENSMUSG00000038224
  
Biological name :Serpinf2
  
Synonyms : Q61247 / serine (or cysteine) peptidase inhibitor, clade F, member 2 / Serpinf2
  
Possible biological names infered from orthology : P08697 / serpin family F member 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75431732
Gene end: 75439591
  
Corresponding Affymetrix probe sets: 10388440 (MoGene1.0st)   1417498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120812
Ensembl peptide - ENSMUSP00000048704
Ensembl peptide - ENSMUSP00000104076
Ensembl peptide - ENSMUSP00000114450
NCBI entrez gene - 18816     See in Manteia.
MGI - MGI:107173
RefSeq - NM_008878
RefSeq Peptide - NP_032904
swissprot - E9PXE0
swissprot - Q5ND35
swissprot - Q5ND36
swissprot - Q61247
Ensembl - ENSMUSG00000038224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinf2aENSDARG00000076448Danio rerio
 serpinf2bENSDARG00000061383Danio rerio
 SERPINF2ENSGALG00000002987Gallus gallus
 P08697ENSG00000167711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97298 / Serpinf1 / Pigment epithelium-derived factor / P36955* / serpin family F member 1*ENSMUSG0000000075324
P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*ENSMUSG0000002322424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033833  Alpha2-antiplasmin
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002034 regulation of blood vessel diameter by renin-angiotensin IMP
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051918 negative regulation of fibrinolysis ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction / complex






 

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