Manteia - Molecule gene

ENSMUSG00000059481

Mus musculus

Features

Gene ID:	ENSMUSG00000059481

Biological name :	Plg

Synonyms :	P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / Plg

Possible biological names infered from orthology :	lipoprotein(a) / LPA / P00747 / P08519 / plasminogen

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	A1
Gene start:	12378609
Gene end:	12419384

Corresponding Affymetrix probe sets:	10441753 (MoGene1.0st) 1416729_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000014578 NCBI entrez gene - 18815 See in Manteia. MGI - MGI:97620 RefSeq - NM_008877 RefSeq Peptide - NP_032903 swissprot - P20918 Ensembl - ENSMUSG00000059481

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
plg	ENSDARG00000023111	Danio rerio
	ENSGALG00000028886	Gallus gallus
	ENSGALG00000004293	Gallus gallus
LPA	ENSG00000198670	Homo sapiens
PLG	ENSG00000122194	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mst1 / P26928 / macrophage stimulating 1 (hepatocyte growth factor-like) / macrophage stimulating 1*	ENSMUSG00000032591	36
Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*	ENSMUSG00000028864	33
F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*	ENSMUSG00000027249	23
Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*	ENSMUSG00000031538	22
Hgfac / Q9R098 / hepatocyte growth factor activator / Q04756* / HGF activator*	ENSMUSG00000029102	20
Habp2 / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA. / Q14520* / hyaluronan binding protein 2*	ENSMUSG00000025075	20
F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*	ENSMUSG00000021492	20
Plau / P06869 / plasminogen activator, urokinase / P00749*	ENSMUSG00000021822	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR000001	Kringle
IPR001254	Serine proteases, trypsin domain
IPR001314	Peptidase S1A, chymotrypsin family
IPR003609	PAN/Apple domain
IPR009003	Peptidase S1, PA clan
IPR013806	Kringle-like fold
IPR018056	Kringle, conserved site
IPR018114	Serine proteases, trypsin family, histidine active site
IPR023317	Peptidase S1A, plasmin
IPR033116	Serine proteases, trypsin family, serine active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	ISO
biological_process	GO:0007596	blood coagulation	ISS
biological_process	GO:0007599	hemostasis	IEA
biological_process	GO:0010812	negative regulation of cell-substrate adhesion	ISO
biological_process	GO:0016525	negative regulation of angiogenesis	TAS
biological_process	GO:0022617	extracellular matrix disassembly	ISO
biological_process	GO:0042246	tissue regeneration	IMP
biological_process	GO:0042730	fibrinolysis	IEA
biological_process	GO:0045445	myoblast differentiation	IMP
biological_process	GO:0046716	muscle cell cellular homeostasis	IMP
biological_process	GO:0048771	tissue remodeling	IEA
biological_process	GO:0051603	proteolysis involved in cellular protein catabolic process	IEA
biological_process	GO:0051702	interaction with symbiont	ISO
biological_process	GO:0051918	negative regulation of fibrinolysis	ISO
biological_process	GO:0051919	positive regulation of fibrinolysis	ISO
biological_process	GO:0052182	modification by host of symbiont morphology or physiology via secreted substance	ISO
biological_process	GO:0052213	interaction with symbiont via secreted substance involved in symbiotic interaction	ISO
biological_process	GO:0060707	trophoblast giant cell differentiation	IMP
biological_process	GO:0060716	labyrinthine layer blood vessel development	IMP
biological_process	GO:0071674	mononuclear cell migration	IMP
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	ISO
cellular_component	GO:0019897	extrinsic component of plasma membrane	IDA
cellular_component	GO:0031232	extrinsic component of external side of plasma membrane	ISO
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0044218	other organism cell membrane	ISO
molecular_function	GO:0004175	endopeptidase activity	IEA
molecular_function	GO:0004252	serine-type endopeptidase activity	TAS
molecular_function	GO:0005102	signaling receptor binding	ISO
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0019900	kinase binding	IPI
molecular_function	GO:0019904	protein domain specific binding	ISO
molecular_function	GO:0034185	apolipoprotein binding	ISO
molecular_function	GO:0051087	chaperone binding	ISO
molecular_function	GO:1904854	proteasome core complex binding	ISO
molecular_function	GO:1990405	protein antigen binding	ISO

Pathways (from Reactome)

Pathway description

Platelet degranulation

Degradation of the extracellular matrix

Activation of Matrix Metalloproteinases

Signaling by PDGF

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Dissolution of Fibrin Clot

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Serpine1^tm1Mlg/Serpine1^tm1Mlg Genetic Background: B6.129S2-Serpine1^tm1Mlg/J
MP:0000470	abnormal stomach morphology	"malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000492	abnormal rectum morphology	"structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas Allelic Composition: Plg^tm1.1Fjc/Plg^tm1.1Fjc Genetic Background: involves: C57BL/6 * C57BL/6JJcl
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Plg^tm1Dco/Plg^tm1Dco,Tg(Alb-PLG)1Dgi/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Plg^tm1.1Fjc/Plg^tm1.1Fjc Genetic Background: involves: C57BL/6 * C57BL/6JJcl
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000512	intestinal ulcer	"lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fga^tm1Jld/Fga^tm1Jld,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000628	abnormal mammary gland development	"aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hspa4l^tm1Imad/Hspa4l^tm1Imad Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas Allelic Composition: Plg^tm1.1Fjc/Plg^tm1.1Fjc Genetic Background: involves: C57BL/6 * C57BL/6JJcl
MP:0001139	abnormal vagina morphology	"malformation of the female reproductive canal located between the uterus and the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fbn1^tm1Hcd/Fbn1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Plg^tm1Dco/Plg^tm1Dco,Tg(Alb-PLG)1Dgi/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Mtm1^tm1.2Jman/Y,Tg(ACTA1-cre)79Jme/? Genetic Background: involves: 129T1/Sv * C57BL/6 * SJL Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001273	decreased metastatic potential		Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001310	abnormal conjunctiva morphology	"malformation or atrophy of the mucous membrane that lines the inner surface of the eyelids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001654	hepatic necrosis	"pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001656	focal hepatic necrosis	"a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fga^tm1Jld/Fga^tm1Jld,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rapgef3^tm1.2Chen/Rapgef3^tm1.2Chen,Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
MP:0001792	impaired wound healing	"reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001845	abnormal inflammatory response	"aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp,Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cpb2^tm1Efp/Cpb2⁺,Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp,Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0001851	eye inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001852	conjunctivitis	"inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001882	abnormal lactation	"atypical production of milk from the mammary gland" [J:51296]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbn1^tm1Hcd/Fbn1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002249	abnormal larynx morphology	"any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0002282	abnormal trachea morphology	"structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0002551	abnormal blood coagulation	"altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fga^tm1Jld/Fga^tm1Jld,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1 Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp,Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cpb2^tm1Efp/Cpb2⁺,Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cpb2^tm1Efp/Cpb2⁺,Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp,Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Plg^tm1Dco/Plg⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003271	abnormal duodenum morphology	"malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fga^tm1Jld/Fga^tm1Jld,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1
MP:0003273	duodenal ulcer	"a lesion on the mucosal surface of the duodenum, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003282	gastric ulcer	"a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003300	gastrointestinal ulcer	"any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003305	proctitis	"local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Plg^tm1.1Fjc/Plg^tm1.1Fjc Genetic Background: involves: C57BL/6 * C57BL/6JJcl
MP:0003434	resistance to induced choroidal neovascularization	"reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Dnd1^Ter/Dnd1⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: G6pc^tm2.2Jyc/G6pc^tm2.2Jyc Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0003893	increased hepatocyte proliferation	"anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004481	abnormal conjunctival epithelium	"any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0004547	esophageal ulcer	"a lesion on the mucosal surface of the esophagus, usually produced by the sloughing of inflammatory necrotic tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0005023	abnormal wound healing	"aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fga^tm1Jld/Fga^tm1Jld,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1
MP:0005035	perianal ulceration	"lesion around or near the anus" [cml:Cathy M Lutz , Mouse Genome Informatics Curator, J:71506]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0005300	abnormal corneal stroma morphology	"structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres,Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ttc7^fsn/Ttc7^fsn Genetic Background: A/J Allelic Composition: Plg^tm1Jld/Plg⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006000	abnormal corneal epithelium	"malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0006050	pulmonary fibrosis	"formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0006137	venoocclusion	"blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006164	ectropion	"abnormal eversion of the upper or lower eyelid that leaves the eye exposed and dry" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0006203	eye hemorrhage	"bleeding into the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0006270	abnormal mammary gland growth during lactation	"anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J
MP:0006271	abnormal involution of the mammary gland	"anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J
MP:0008236	decreased susceptibility to neuronal excitotoxicity	"less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: G6pc^tm2.2Jyc/G6pc^tm2.2Jyc Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
MP:0009507	abnormal mammary gland connective tissue morphology	"any structural anomaly of the fibrous supportive tissue of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas
MP:0009764	decreased sensitivity to induced morbidity/mortality	"increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: B6.129P2-Plg^tm1Jld
MP:0010211	abnormal acute phase protein level	"deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0010249	lactation failure	"mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J
MP:0011507	kidney thrombosis	"formation or presence of a thrombus within the blood vessel network of the organ of secretion" [MGI:anna]	Show Allelic Composition: Plg^tm1Jld/Plg^tm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0012331	increased circulating fibrinogen level	"greater levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Plg^tm1Dco/Plg^tm1Dco Genetic Background: involves: 129S2/SvPas Allelic Composition: Plg^tm1.1Fjc/Plg^tm1.1Fjc Genetic Background: involves: C57BL/6 * C57BL/6JJcl

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000046070	Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*	/ reaction
ENSMUSG00000050578	Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*	/ reaction
ENSMUSG00000048583	Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*	/ reaction
ENSMUSG00000031538	Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*	/ reaction / complex
ENSMUSG00000046223	Plaur / P35456 / plasminogen activator, urokinase receptor / Q03405*	/ reaction
ENSMUSG00000020053	Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*	/ reaction
ENSMUSG00000032006	Pdgfd / Q925I7 / Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA. / Q9GZP0* / platelet derived growth factor D*	/ reaction
ENSMUSG00000021822	Plau / P06869 / plasminogen activator, urokinase / P00749*	/ reaction
ENSMUSG00000028019	Pdgfc / Q8CI19 / platelet-derived growth factor, C polypeptide / Q9NRA1* / platelet derived growth factor C*	/ reaction
ENSMUSG00000028763	Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*	/ reaction
ENSMUSG00000020427	Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*	/ reaction
ENSMUSG00000059481	Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*	/ complex
ENSMUSG00000022877	Hrg / histidine rich glycoprotein / P04196*	/ complex / reaction
ENSMUSG00000038224	Q61247 / Serpinf2 / serine (or cysteine) peptidase inhibitor, clade F, member 2 / P08697* / serpin family F member 2*	/ complex / reaction

1 s.

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