ENSMUSG00000032591


Mus musculus

Features
Gene ID: ENSMUSG00000032591
  
Biological name :Mst1
  
Synonyms : macrophage stimulating 1 (hepatocyte growth factor-like) / Mst1 / P26928
  
Possible biological names infered from orthology : macrophage stimulating 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 108080436
Gene end: 108085003
  
Corresponding Affymetrix probe sets: 10588855 (MoGene1.0st)   1418267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141729
Ensembl peptide - ENSMUSP00000035211
Ensembl peptide - ENSMUSP00000125175
Ensembl peptide - ENSMUSP00000125462
NCBI entrez gene - 15235     See in Manteia.
MGI - MGI:96080
RefSeq - XM_011242856
RefSeq - NM_008243
RefSeq - XM_006511639
RefSeq Peptide - NP_032269
swissprot - A0A0A6YWW4
swissprot - P26928
swissprot - F7C0X2
swissprot - E0CXN0
Ensembl - ENSMUSG00000032591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mst1ENSDARG00000103308Danio rerio
 MST1ENSGALG00000002722Gallus gallus
 MST1ENSG00000173531Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*ENSMUSG0000002886442
Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*ENSMUSG0000005948141
F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*ENSMUSG0000002724922
Hgfac / Q9R098 / hepatocyte growth factor activator / Q04756* / HGF activator*ENSMUSG0000002910220
Habp2 / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA. / Q14520* / hyaluronan binding protein 2*ENSMUSG0000002507519
F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*ENSMUSG0000002149219
Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*ENSMUSG0000003153817
Plau / P06869 / plasminogen activator, urokinase / P00749*ENSMUSG0000002182215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003609  PAN/Apple domain
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR024174  Hepatocyte growth factor-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010758 regulation of macrophage chemotaxis IMP
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0045721 negative regulation of gluconeogenesis ISO
 biological_processGO:0046425 regulation of JAK-STAT cascade IMP
 biological_processGO:0060763 mammary duct terminal end bud growth IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1904036 negative regulation of epithelial cell apoptotic process IMP
 biological_processGO:2000479 regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005773 vacuole IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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