Manteia

ENSMUSG00000029102

Mus musculus

Features

Gene ID:	ENSMUSG00000029102

Biological name :	Hgfac

Synonyms :	hepatocyte growth factor activator / Hgfac / Q9R098

Possible biological names infered from orthology :	HGF activator / Q04756

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	B2
Gene start:	35041509
Gene end:	35048461

Corresponding Affymetrix probe sets:	10521356 (MoGene1.0st) 1418405_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000144402 Ensembl peptide - ENSMUSP00000030985 Ensembl peptide - ENSMUSP00000144344 NCBI entrez gene - 54426 See in Manteia. MGI - MGI:1859281 RefSeq - XM_017320997 RefSeq - NM_019447 RefSeq - XM_006504031 RefSeq - XM_006504032 RefSeq - XM_006504033 RefSeq Peptide - NP_062320 swissprot - Q9R098 swissprot - A0A0J9YUY6 swissprot - A0A0J9YUU2 swissprot - Q545J3 Ensembl - ENSMUSG00000029102

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*	ENSMUSG00000021492	37
Habp2 / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA. / Q14520* / hyaluronan binding protein 2*	ENSMUSG00000025075	29
Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*	ENSMUSG00000031538	27
Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*	ENSMUSG00000059481	25
Plau / P06869 / plasminogen activator, urokinase / P00749*	ENSMUSG00000021822	23
Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*	ENSMUSG00000028864	22
Mst1 / P26928 / macrophage stimulating 1 (hepatocyte growth factor-like) / macrophage stimulating 1*	ENSMUSG00000032591	22
F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*	ENSMUSG00000027249	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000001	Kringle
IPR000083	Fibronectin, type I
IPR000562	Fibronectin type II domain
IPR000742	EGF-like domain
IPR001254	Serine proteases, trypsin domain
IPR001314	Peptidase S1A, chymotrypsin family
IPR009003	Peptidase S1, PA clan
IPR013032	EGF-like, conserved site
IPR013806	Kringle-like fold
IPR014394	Coagulation factor XII/hepatocyte growth factor activator
IPR018056	Kringle, conserved site
IPR018114	Serine proteases, trypsin family, histidine active site
IPR033116	Serine proteases, trypsin family, serine active site
IPR036943	Fibronectin type II domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005791	rough endoplasmic reticulum	IDA
molecular_function	GO:0004252	serine-type endopeptidase activity	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

MET Receptor Activation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003380	abnormal intestine regeneration	"deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Met^tm3Kln/Met^tm3Kln Genetic Background: involves: 129/Sv * C57BL/6 * CD-1
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Met^tm3Kln/Met^tm3Kln Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000029102	Hgfac / Q9R098 / hepatocyte growth factor activator / Q04756* / HGF activator*	/ complex
ENSMUSG00000028864	Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr