ENSG00000109758


Homo sapiens

Features
Gene ID: ENSG00000109758
  
Biological name :HGFAC
  
Synonyms : HGFAC / HGF activator / Q04756
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 3441887
Gene end: 3449495
  
Corresponding Affymetrix probe sets: 207027_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421801
Ensembl peptide - ENSP00000372224
NCBI entrez gene - 3083     See in Manteia.
OMIM - 604552
RefSeq - NM_001297439
RefSeq - NM_001528
RefSeq Peptide - NP_001284368
RefSeq Peptide - NP_001519
swissprot - Q04756
swissprot - D6RAR4
Ensembl - ENSG00000109758
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HGFACENSGALG00000015623Gallus gallus
 HgfacENSMUSG00000029102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F12 / P00748 / coagulation factor XIIENSG0000013118736
PLAT / P00750 / plasminogen activator, tissue typeENSG0000010436828
HABP2 / Q14520 / hyaluronan binding protein 2ENSG0000014870228
PLG / P00747 / plasminogenENSG0000012219426
LPA / P08519 / lipoprotein(a)ENSG0000019867025
MST1 / macrophage stimulating 1ENSG0000017353124
PLAU / P00749 / plasminogen activator, urokinaseENSG0000012286124
HGF / P14210 / hepatocyte growth factorENSG0000001999122
F2 / P00734 / coagulation factor II, thrombinENSG0000018021021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000083  Fibronectin, type I
 IPR000562  Fibronectin type II domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR013806  Kringle-like fold
 IPR014394  Coagulation factor XII/hepatocyte growth factor activator
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109758 HGFAC / Q04756 / HGF activator  / complex
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr