ENSG00000198670


Homo sapiens

Features
Gene ID: ENSG00000198670
  
Biological name :LPA
  
Synonyms : lipoprotein(a) / LPA / P08519
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q26
Gene start: 160531483
Gene end: 160664259
  
Corresponding Affymetrix probe sets: 207584_at (Human Genome U133 Plus 2.0 Array)   209978_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395608
Ensembl peptide - ENSP00000480589
Ensembl peptide - ENSP00000321334
NCBI entrez gene - 4018     See in Manteia.
OMIM - 152200
RefSeq - NM_005577
RefSeq Peptide - NP_005568
swissprot - A0A087WWY0
swissprot - P08519
Ensembl - ENSG00000198670
  
Related genetic diseases (OMIM): 152200 - [LPA deficiency, congenital]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plgENSDARG00000023111Danio rerio
 ENSGALG00000028886Gallus gallus
 ENSGALG00000004293Gallus gallus
 PlgENSMUSG00000059481Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLG / P00747 / plasminogenENSG0000012219424
MST1 / macrophage stimulating 1ENSG0000017353113
HGF / P14210 / hepatocyte growth factorENSG0000001999113
F2 / P00734 / coagulation factor II, thrombinENSG000001802108
HABP2 / Q14520 / hyaluronan binding protein 2ENSG000001487028
HGFAC / Q04756 / HGF activatorENSG000001097588
F12 / P00748 / coagulation factor XIIENSG000001311878
PLAT / P00750 / plasminogen activator, tissue typeENSG000001043688
PLAU / P00749 / plasminogen activator, urokinaseENSG000001228617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0034358 plasma lipoprotein particle IDA
 molecular_functionGO:0001968 fibronectin binding IPI
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding NAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034185 apolipoprotein binding IPI


Pathways (from Reactome)
Pathway description
LDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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