ENSG00000019991


Homo sapiens

Features
Gene ID: ENSG00000019991
  
Biological name :HGF
  
Synonyms : hepatocyte growth factor / HGF / P14210
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.11
Gene start: 81699008
Gene end: 81770438
  
Corresponding Affymetrix probe sets: 209960_at (Human Genome U133 Plus 2.0 Array)   209961_s_at (Human Genome U133 Plus 2.0 Array)   210755_at (Human Genome U133 Plus 2.0 Array)   210997_at (Human Genome U133 Plus 2.0 Array)   210998_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396307
Ensembl peptide - ENSP00000408270
Ensembl peptide - ENSP00000496217
Ensembl peptide - ENSP00000494899
Ensembl peptide - ENSP00000494355
Ensembl peptide - ENSP00000413829
Ensembl peptide - ENSP00000222390
Ensembl peptide - ENSP00000346164
Ensembl peptide - ENSP00000388592
Ensembl peptide - ENSP00000389854
Ensembl peptide - ENSP00000391238
NCBI entrez gene - 3082     See in Manteia.
OMIM - 142409
RefSeq - XM_006715956
RefSeq - XM_017012098
RefSeq - XM_017012097
RefSeq - XM_011516115
RefSeq - NM_000601
RefSeq - NM_001010931
RefSeq - NM_001010932
RefSeq - NM_001010933
RefSeq - NM_001010934
RefSeq Peptide - NP_000592
RefSeq Peptide - NP_001010931
RefSeq Peptide - NP_001010932
RefSeq Peptide - NP_001010933
RefSeq Peptide - NP_001010934
swissprot - P14210
swissprot - C9WSJ4
swissprot - C9JDP4
swissprot - C9JS80
swissprot - C9WSJ3
Ensembl - ENSG00000019991
  
Related genetic diseases (OMIM): 608265 - Deafness, autosomal recessive 39, 608265
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hgfaENSDARG00000045544Danio rerio
 hgfbENSDARG00000079076Danio rerio
 HGFENSGALG00000033974Gallus gallus
 HgfENSMUSG00000028864Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MST1 / macrophage stimulating 1ENSG0000017353143
PLG / P00747 / plasminogenENSG0000012219437
LPA / P08519 / lipoprotein(a)ENSG0000019867035
F2 / P00734 / coagulation factor II, thrombinENSG0000018021021
HGFAC / Q04756 / HGF activatorENSG0000010975820
F12 / P00748 / coagulation factor XIIENSG0000013118720
HABP2 / Q14520 / hyaluronan binding protein 2ENSG0000014870218
PLAT / P00750 / plasminogen activator, tissue typeENSG0000010436816
PLAU / P00749 / plasminogen activator, urokinaseENSG0000012286115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR003609  PAN/Apple domain
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR024174  Hepatocyte growth factor-like
 IPR027284  Hepatocyte growth factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0000278 mitotic cell cycle NAS
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001837 epithelial to mesenchymal transition TAS
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010507 negative regulation of autophagy NAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031643 positive regulation of myelination IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation NAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II NAS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IDA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
 biological_processGO:0070572 positive regulation of neuron projection regeneration IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:1900744 regulation of p38MAPK cascade IEA
 biological_processGO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902947 regulation of tau-protein kinase activity IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity NAS
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Interleukin-7 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000399 Deafness, sensorineural, prelingual, profound 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / reaction / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / reaction / complex
 ENSG00000141084 Q6VN20 / RANBP10 / RAN binding protein 10  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000176945 MUC20 / Q8N307 / mucin 20, cell surface associated  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000010017 Q96S59 / RANBP9 / RAN binding protein 9  / complex / reaction
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000131746 TNS4 / Q8IZW8 / tensin 4  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / reaction / complex
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / complex / reaction
 ENSG00000165527 ARF6 / P62330 / ADP ribosylation factor 6  / complex
 ENSG00000104432 IL7 / P13232 / interleukin 7  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000105707 HPN / hepsin / P05981  / reaction
 ENSG00000175354 PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2  / reaction
 ENSG00000136205 TNS3 / Q68CZ2 / tensin 3  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000109758 HGFAC / Q04756 / HGF activator  / reaction
 ENSG00000149177 PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J  / reaction






 

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