ENSG00000010017


Homo sapiens

Features
Gene ID: ENSG00000010017
  
Biological name :RANBP9
  
Synonyms : Q96S59 / RAN binding protein 9 / RANBP9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p23
Gene start: 13621498
Gene end: 13711564
  
Corresponding Affymetrix probe sets: 202582_s_at (Human Genome U133 Plus 2.0 Array)   202583_s_at (Human Genome U133 Plus 2.0 Array)   216125_s_at (Human Genome U133 Plus 2.0 Array)   243108_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000011619
NCBI entrez gene - 10048     See in Manteia.
OMIM - 603854
RefSeq - XM_017010149
RefSeq - NM_005493
RefSeq - XM_006714945
RefSeq - XM_011514205
RefSeq Peptide - NP_005484
swissprot - A0A024QZW3
swissprot - Q96S59
Ensembl - ENSG00000010017
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ranbp9ENSDARG00000061048Danio rerio
 RANBP9ENSGALG00000012696Gallus gallus
 P69566ENSMUSG00000038546Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6VN20 / RANBP10 / RAN binding protein 10ENSG0000014108458
Q8NCJ5 / SPRYD3 / SPRY domain containing 3ENSG0000016777812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR006594  LIS1 homology motif
 IPR006595  CTLH, C-terminal LisH motif
 IPR013144  CRA domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR024964  CTLH/CRA C-terminal to LisH motif domain
 IPR035782  Ran binding protein 9/10, SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007020 microtubule nucleation TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005875 microtubule associated complex TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008536 Ran GTPase binding TAS
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
L1CAM interactions
RAF/MAP kinase cascade
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex






 

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