ENSG00000115904


Homo sapiens

Features
Gene ID: ENSG00000115904
  
Biological name :SOS1
  
Synonyms : Q07889 / SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p22.1
Gene start: 38981396
Gene end: 39124345
  
Corresponding Affymetrix probe sets: 1557354_at (Human Genome U133 Plus 2.0 Array)   212777_at (Human Genome U133 Plus 2.0 Array)   212780_at (Human Genome U133 Plus 2.0 Array)   227426_at (Human Genome U133 Plus 2.0 Array)   230337_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393899
Ensembl peptide - ENSP00000378479
Ensembl peptide - ENSP00000384675
Ensembl peptide - ENSP00000387784
NCBI entrez gene - 6654     See in Manteia.
OMIM - 182530
RefSeq - XM_011533066
RefSeq - NM_005633
RefSeq - XM_005264515
RefSeq - XM_011533062
RefSeq - XM_011533064
RefSeq Peptide - NP_005624
swissprot - G5E9C8
swissprot - C9K0N6
swissprot - Q07889
Ensembl - ENSG00000115904
  
Related genetic diseases (OMIM): 135300 - ?Fibromatosis, gingival, 1, 135300
  610733 - Noonan syndrome 4, 610733
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sos1ENSDARG00000100503Danio rerio
 SOS1ENSGALG00000039450Gallus gallus
 Sos1ENSMUSG00000024241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2ENSG0000010048570
Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1ENSG0000010726317
Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1ENSG0000005833513
Q12967 / RALGDS / ral guanine nucleotide dissociation stimulatorENSG0000016027112
O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2ENSG0000011331912
AL162417.1ENSG0000028524511
RGL1 / Q9NZL6 / ral guanine nucleotide dissociation stimulator like 1ENSG0000014334411
RGL3 / Q3MIN7 / ral guanine nucleotide dissociation stimulator like 3ENSG0000020551710
RGL2 / O15211 / ral guanine nucleotide dissociation stimulator like 2ENSG000002374419
Q5JS13 / RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1ENSG000001368287
Q86X27 / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2ENSG000001161917
RGL4 / Q8IZJ4 / ral guanine nucleotide dissociation stimulator like 4ENSG000001594967


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003209 cardiac atrium morphogenesis IEA
 biological_processGO:0003344 pericardium morphogenesis IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007296 vitellogenesis IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008286 insulin receptor signaling pathway TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0033081 regulation of T cell differentiation in thymus IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042129 regulation of T cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0061384 heart trabecula morphogenesis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904693 midbrain morphogenesis IEA
 biological_processGO:2000973 regulation of pro-B cell differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Interleukin-15 signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000028 Cryptorchidism "Absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the testis." [HPO:curators]
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 HP:0000044 Hypogonadotrophic hypogonadism "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." [HPO:curators]
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 HP:0000169 Gingival fibromatosis "Gingival fibromatosis is characterized by a slowly progressive benign enlargement of the oral gingival tissues. The condition results in the teeth being partially or totally engulfed by keratinized gingiva, causing aesthetic and functional problems. Both genetic and pharmacologically induced forms of gingival fibromatosis are known. The most common genetic form, hereditary gingival fibromatosis (HGF), is usually transmitted as an autosomal dominant trait, although sporadic cases are common and autosomal recessive inheritance has been reported." [HPO:curators]
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 HP:0000179 Prominent lower lip "Increased thickness of the lower lip, leading to a prominent appearance of the lower lip." [HPO:curators]
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 HP:0000212 Gingival hyperplasia 
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 HP:0000218 High palate "Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective)." [pmid:19125428]
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 HP:0000256 Macrocephaly "The presence of an abnormally large `skull` (FMA:46565)." [HPO:probinson]
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 HP:0000286 Epicanthus "An epicanthal fold is a semilunar fold of skin that extends from the upper eyelid across the medial canthal area to the lower eyelid." [HPO:curators]
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 HP:0000316 Hypertelorism 
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 HP:0000325 Triangular facies 
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 HP:0000347 Mandibular hypoplasia "Underdevelopment of the mandible." [HPO:curators]
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 HP:0000348 High forehead "An abnormally increased height of the forehead." [HPO:curators]
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 HP:0000368 Low-set, posteriorly rotated ears 
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 HP:0000391 Thickened helices 
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 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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 HP:0000465 Webbed neck 
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 HP:0000470 Short neck 
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 HP:0000474 Excess nuchal skin 
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 HP:0000476 Cystic hygroma of the neck "A cystic lymphatic lesion of the neck." [HPO:curators]
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 HP:0000486 Strabismus "Strabismus (also known as squint) is a condition in which the eyes are not properly aligned with each other." [HPO:curators]
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 HP:0000494 Downward slanting palpebral fissures 
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 HP:0000508 Ptosis "Drooping of the eyelid." [HPO:curators]
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 HP:0000520 Proptosis 
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 HP:0000535 Sparse eyebrows 
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 HP:0000635 Blue irides 
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 HP:0000639 Nystagmus "Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." [HPO:curators]
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 HP:0000689 Dental malocclusion "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." [HPO:curators]
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 HP:0000767 Pectus excavatum "A defect of the chest wall characterized by a depression of the sternum, giving the chest ("pectus") a caved-in ("excavatum") appearance." [HPO:curators]
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 HP:0000768 Pectus carinatum "A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum." [HPO:curators]
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 HP:0000915 Pectus excavatum inferiorly "Pectus excavatum (defect of the chest wall characterized by depression of the sternum) affecting primarily the inferior region of the sternum." [HPO:curators]
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 HP:0000995 Pigmented nevi "The presence of increased numbers of pigmented nevi, that is, of small, dark spots on the skin. Pigmented nevi are also known as melanocytic nevi or moles." [HPO:curators]
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 HP:0001004 Lymphedema 
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 HP:0001156 Brachydactyly 
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 HP:0001252 Muscular hypotonia "Muscular hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle), often involving reduced muscle strength. Hypotonia is characterized by a diminished resistance to passive stretching." [HPO:curators]
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 HP:0001260 Dysarthria "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." [HPO:curators]
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 HP:0001324 Muscle weakness "Reduced strength of muscles." [HPO:curators]
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 HP:0001629 Ventricular septal defect "A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum." [HPO:curators]
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 HP:0001639 Hypertrophic cardiomyopathy 
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 HP:0001641 Abnormality of the pulmonary valve "An abnormality of the `pulmonary valve` (FMA:7246)." [HPO:probinson]
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 HP:0001642 Pulmonic stenosis "A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis) or just below the pulmonary valve (infundibular stenosis). Infundibular pulmonic stenosis is mostly caused by overgrowth of the heart muscle wall (hypertrophy of the septoparietal trabeculae). Pulmonic stenosis is often seen as a part of Fallot s tetralogy, in which case the events leading to the formation of the overriding aorta are also believed to be a cause of the pulmonic stenosis. The pulmonic stenosis is the major cause of the malformations seen in patients with Fallot tetralogy, with the other associated malformations acting as compensatory mechanisms to the pulmonic stenosis. The degree of stenosis varies between individuals with TOF, and is the primary determinant of symptoms and severity. This malformation is infrequently described as sub-pulmonary stenosis or subpulmonary obstruction." [HPO:curators]
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 HP:0001743 Abnormality of the spleen 
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 HP:0001892 Bleeding diathesis "An abnormal susceptibility to bleeding because of a defect in coagulation." [HPO:curators]
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 HP:0001928 Abnormality of coagulation 
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 HP:0002162 Low posterior hairline 
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 HP:0002208 Coarse hair 
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 HP:0002212 Curly hair 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002650 Scoliosis "The presence of an abnormal lateral curvature of the spine." [HPO:curators]
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 HP:0002750 Delayed skeletal maturation "A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." [HPO:curators]
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 HP:0002967 Cubitus valgus 
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 HP:0002974 Radioulnar synostosis "An abnormal osseous union (fusion) between the radius and the ulna." [HPO:curators]
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 HP:0003010 Prolonged bleeding time 
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 HP:0004209 Clinodactyly of the 5th finger "Clinodactyly refers to a bending or curvature of the `fifth finger` (FMA:24949) in the radial direction (i.e., towards the 4th finger)." [HPO:curators]
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0004415 Pulmonary artery stenosis 
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 HP:0005280 Depressed nasal root and bridge 
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 HP:0005692 Joint hyperflexibility 
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 HP:0006610 Wide intermamillary distance 
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 HP:0007477 Abnormal dermatoglyphics "An abnormality of dermatoglyphs (fingerprints), which are present on fingers, palms, toes, and soles." [HPO:curators]
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 HP:0008872 Feeding problems in infancy 
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 HP:0009890 High frontal hairline "An abnormally high hairline (border between forehead and scalp hair)." [HPO:curators]
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 HP:0010318 Aplasia/Hypoplasia of the abdominal wall musculature "Absence or underdevelopment of the abdominal wall musculature." [HPO:curators]
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 HP:0011362 Abnormal hair quantity "An abnormal amount of hair." [DDD:cmoss]
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 HP:0011381 Aplasia of the semicircular canal "Absence of the semicircular canal." [DDD:dfitzpatrick]
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 HP:0011675 Arrhythmia "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." [DDD:dbrown, pmid:19063792]
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 HP:0011800 Midface retrusion "Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle." [DDD:jclayton-smith]
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 HP:0011869 Abnormal platelet function "Any anomaly in the function of thrombocytes." [HPO:probinson]
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 HP:0100625 Enlarged thorax 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000132670 PTPRA / P18433 / protein tyrosine phosphatase, receptor type A  / reaction / complex
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / reaction / complex
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000095585 BLNK / Q8WV28 / B cell linker  / complex
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000130427 EPO / P01588 / erythropoietin  / reaction / complex
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction / complex
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / reaction / complex
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / reaction / complex
 ENSG00000137218 FRS3 / O43559 / fibroblast growth factor receptor substrate 3  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000129946 SHC2 / P98077 / SHC adaptor protein 2  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / reaction / complex
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / reaction / complex
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000147475 ERLIN2 / O94905 / ER lipid raft associated 2  / reaction / complex
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / reaction / complex
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / reaction / complex
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction / complex
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / reaction / complex
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / complex / reaction
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / complex
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / reaction / complex
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / complex / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction / complex
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / reaction / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / reaction / complex
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000148082 SHC3 / Q92529 / SHC adaptor protein 3  / reaction / complex
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / reaction / complex
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction / complex
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex / reaction
 ENSG00000105369 CD79A / P11912 / CD79a molecule  / reaction / complex
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / complex / reaction
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / reaction / complex
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000090554 FLT3LG / P49771 / fms related tyrosine kinase 3 ligand  / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000007312 CD79B / P40259 / CD79b molecule  / reaction / complex
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000122025 FLT3 / P36888 / fms related tyrosine kinase 3  / complex
 ENSG00000010017 Q96S59 / RANBP9 / RAN binding protein 9  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / reaction / complex
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / complex / reaction
 ENSG00000211899 IGHM / P01871 / immunoglobulin heavy constant mu  / reaction / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000211898 IGHD / P01880 / immunoglobulin heavy constant delta  / complex / reaction
 ENSG00000113525 IL5 / P05113 / interleukin 5  / reaction / complex
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction / complex
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / reaction / complex






 

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