ENSG00000225950


Homo sapiens

Features
Gene ID: ENSG00000225950
  
Biological name :NTF4
  
Synonyms : neurotrophin 4 / NTF4 / P34130
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49061066
Gene end: 49065054
  
Corresponding Affymetrix probe sets: 231785_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471508
Ensembl peptide - ENSP00000469455
NCBI entrez gene - 4909     See in Manteia.
OMIM - 162662
RefSeq - XM_011527010
RefSeq - XM_005258962
RefSeq - XM_006723232
RefSeq - XM_011527008
RefSeq - XM_011527009
RefSeq - NM_006179
RefSeq Peptide - NP_006170
swissprot - M0R0X2
swissprot - A0A024QZE4
swissprot - P34130
Ensembl - ENSG00000225950
  
Related genetic diseases (OMIM): 613100 - Glaucoma 1, open angle, 1O, 613100
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ntf5ENSMUSG00000074121Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BDNF / P23560 / brain derived neurotrophic factorENSG0000017669742
NTF3 / P20783 / neurotrophin 3ENSG0000018565240
NGF / P01138 / nerve growth factorENSG0000013425936


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020432  Neurotrophin-4
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007402 ganglion mother cell fate determination ISS
 biological_processGO:0007616 long-term memory ISS
 biological_processGO:0008052 sensory organ boundary specification ISS
 biological_processGO:0008344 adult locomotory behavior ISS
 biological_processGO:0008544 epidermis development ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042490 mechanoreceptor differentiation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061193 taste bud development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0012108 Primary open angle glaucoma "A type of glaucoma with optic nerve damage in an eye with evidence of significant obstruction of the functional trabecular meshwork by the peripheral iris would be classified as having primary angle closure." [HPO:probinson, pmid:11815354]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000137218 FRS3 / O43559 / fibroblast growth factor receptor substrate 3  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex






 

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