ENSG00000124181


Homo sapiens

Features
Gene ID: ENSG00000124181
  
Biological name :PLCG1
  
Synonyms : P19174 / phospholipase C gamma 1 / PLCG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q12
Gene start: 41136960
Gene end: 41196801
  
Corresponding Affymetrix probe sets: 202789_at (Human Genome U133 Plus 2.0 Array)   216551_x_at (Human Genome U133 Plus 2.0 Array)   240805_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476757
Ensembl peptide - ENSP00000476454
Ensembl peptide - ENSP00000485760
Ensembl peptide - ENSP00000244007
Ensembl peptide - ENSP00000362368
Ensembl peptide - ENSP00000468958
Ensembl peptide - ENSP00000476432
NCBI entrez gene - 5335     See in Manteia.
OMIM - 172420
RefSeq - XM_011528867
RefSeq - NM_002660
RefSeq - NM_182811
RefSeq - XM_005260438
RefSeq - XM_011528865
RefSeq Peptide - NP_877963
RefSeq Peptide - NP_002651
swissprot - V9GY63
swissprot - V9GY71
swissprot - M0QX77
swissprot - V9GYH5
swissprot - A0A0D9SEK2
swissprot - P19174
Ensembl - ENSG00000124181
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcg1ENSDARG00000038442Danio rerio
 PLCG1ENSGALG00000003750Gallus gallus
 Plcg1ENSMUSG00000016933Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCG2 / P16885 / phospholipase C gamma 2ENSG0000019794349
PLCE1 / Q9P212 / phospholipase C epsilon 1ENSG0000013819323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR000980  SH2 domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001452  SH3 domain
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR016279  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028380  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
 IPR035023  PLC-gamma, C-terminal SH2 domain
 IPR035024  PLC-gamma, N-terminal SH2 domain
 IPR035724  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain
 IPR035892  C2 domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor NAS
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0035254 glutamate receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Frs2-mediated activation
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Generation of second messenger molecules
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK3 signals through PLCG1
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction / complex
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / reaction / complex
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000147475 ERLIN2 / O94905 / ER lipid raft associated 2  / reaction / complex
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / complex / reaction
 ENSG00000186716 BCR / P11274 / BCR, RhoGEF and GTPase activating protein  / reaction / complex
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / reaction / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / reaction / complex
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / reaction / complex
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / reaction / complex
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / reaction / complex
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction / complex
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000130427 EPO / P01588 / erythropoietin  / reaction / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / reaction / complex
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction / complex
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction / complex
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / reaction / complex
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / reaction / complex
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / reaction / complex
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / reaction / complex
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction






 

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