ENSG00000213658


Homo sapiens

Features
Gene ID: ENSG00000213658
  
Biological name :LAT
  
Synonyms : LAT / linker for activation of T cells / O43561
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 28984826
Gene end: 28990783
  
Corresponding Affymetrix probe sets: 209881_s_at (Human Genome U133 Plus 2.0 Array)   211005_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455728
Ensembl peptide - ENSP00000492142
Ensembl peptide - ENSP00000488120
Ensembl peptide - ENSP00000457036
Ensembl peptide - ENSP00000456761
Ensembl peptide - ENSP00000354119
Ensembl peptide - ENSP00000378841
Ensembl peptide - ENSP00000378845
Ensembl peptide - ENSP00000398793
Ensembl peptide - ENSP00000454793
NCBI entrez gene - 27040     See in Manteia.
OMIM - 602354
RefSeq - NM_014387
RefSeq - NM_001014987
RefSeq - NM_001014988
RefSeq - NM_001014989
RefSeq Peptide - NP_001014987
RefSeq Peptide - NP_001014989
RefSeq Peptide - NP_055202
RefSeq Peptide - NP_001014988
swissprot - O43561
swissprot - A0A1W2PQT7
swissprot - A0A024QZD6
swissprot - H3BQD8
swissprot - C7C5T5
Ensembl - ENSG00000213658
  
Related genetic diseases (OMIM): 617514 - Immunodeficiency 52, 617514
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LatENSMUSG00000030742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008359  Linker-for-activation of T cells (LAT) protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEP
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050863 regulation of T cell activation IMP
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0008180 COP9 signalosome ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Generation of second messenger molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / complex / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction






 

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