Manteia - Molecule gene

ENSMUSG00000030742

Mus musculus

Features

Gene ID:	ENSMUSG00000030742

Biological name :	Lat

Synonyms :	Lat / Linker for activation of T-cells family member 1 / O54957

Possible biological names infered from orthology :	linker for activation of T cells / O43561

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	F3
Gene start:	126363824
Gene end:	126369570

Corresponding Affymetrix probe sets:	10567825 (MoGene1.0st) 1460651_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146191 Ensembl peptide - ENSMUSP00000032997 Ensembl peptide - ENSMUSP00000145773 NCBI entrez gene - 16797 See in Manteia. MGI - MGI:1342293 RefSeq - XM_006507398 RefSeq - NM_010689 RefSeq - XM_006507396 RefSeq - XM_006507397 RefSeq Peptide - NP_034819 swissprot - O54957 swissprot - Q546H1 swissprot - A0A0U1RQ02 swissprot - A0A0U1RP03 Ensembl - ENSMUSG00000030742

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
LAT	ENSG00000213658	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR008359	Linker-for-activation of T cells (LAT) protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002260	lymphocyte homeostasis	IMP
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006954	inflammatory response	IMP
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0006968	cellular defense response	TAS
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS
biological_process	GO:0007229	integrin-mediated signaling pathway	IEA
biological_process	GO:0007265	Ras protein signal transduction	IEA
biological_process	GO:0009967	positive regulation of signal transduction	IEA
biological_process	GO:0010467	gene expression	IMP
biological_process	GO:0019722	calcium-mediated signaling	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0043303	mast cell degranulation	IEA
biological_process	GO:0045860	positive regulation of protein kinase activity	IEA
biological_process	GO:0048872	homeostasis of number of cells	IMP
biological_process	GO:0050863	regulation of T cell activation	IEA
cellular_component	GO:0001772	immunological synapse	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0005887	integral component of plasma membrane	TAS
cellular_component	GO:0005911	cell-cell junction	IDA
cellular_component	GO:0008180	COP9 signalosome	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	ISO
cellular_component	GO:0042629	mast cell granule	IEA
molecular_function	GO:0005057	obsolete signal transducer activity, downstream of receptor	TAS
molecular_function	GO:0005070	SH3/SH2 adaptor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019901	protein kinase binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Generation of second messenger molecules

DAP12 signaling

Fc epsilon receptor (FCERI) signaling

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

RAF/MAP kinase cascade

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dmtf1^tm1Cjs/Dmtf1^tm1Cjs,Kras^tm3Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Lat^tm8Mal/Lat^tm8Mal Genetic Background: involves: C57BL/6
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov,Lat2^tm1Wz/Lat2^tm1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov,Lat2^tm1Wz/Lat2^tm1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov,Lat2^tm1Wz/Lat2^tm1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000704	abnormal thymus development	"anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lat^tm1Les/Lat^tm1Les Genetic Background: involves: 129P2/OlaHsd
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lat^tm2.1Lov/Lat^tm2.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0000727	absent CD4-8+ cells	"lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: B2m^tm1Unc/B2m^tm1Unc,H2-Ab1^tm1Doi/H2-Ab1^tm1Doi,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas Allelic Composition: Cd3e^tm1Mal/Cd3e^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lat^tm1Les/Lat^tm1Les Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd3e^tm1Mal/Cd3e^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1Les,Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lat^tm1Les/Lat^tm1.2Wz Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Lat^{tm8.1(CD2)Mal}/Lat^{tm8.1(CD2)Mal} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm5Mal/Lat^tm5Mal Genetic Background: involves: C57BL/6
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm6(DTR)Mal/Lat^tm6(DTR)Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001829	increased activated T cell number	"greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lat^tm1Les/Lat^tm1Les Genetic Background: involves: 129P2/OlaHsd
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lat^tm1Les/Lat^tm1Les Genetic Background: involves: 129P2/OlaHsd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gckr^tm1Jfg/Gckr^tm1Jfg Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd74^tm1Doi/Cd74^tm1Doi,H2-DMa^tm1Doi/H2-DMa^tm1Doi Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0002221	abnormal lymph organ size	"change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gckr^tm1Jfg/Gckr^tm1Jfg Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002346	abnormal lymph node secondary follicle	"anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	"anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm8Mal/Lat^tm8Mal Genetic Background: involves: C57BL/6
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Trdc^tm1Mal/Trdc^tm1Mal Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002423	abnormal mast cell physiology	"anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Irs2^tm1Mfw/Irs2^tm1Mfw,Tg(Ins2-Irs2)13Mfw/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal,Lat2^tm1Mal/Lat2^tm1Mal Genetic Background: involves: 129S2/SvPas
MP:0002432	abnormal CD4+ T cell morphology/development	"anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov,Lat2^tm1Wz/Lat2^tm1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002434	abnormal T helper 2 morphology/development	"anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz Genetic Background: involves: C57BL/6
MP:0002439	abnormal plasma cell morphology/development	"anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002442	abnormal leukocyte physiology	"abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat2^tm2Wz/Lat2^tm2Wz,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: C57BL/6
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gckr^tm1Jfg/Gckr^tm1Jfg Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Lat^tm6(DTR)Mal/?,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm8Mal/Lat^tm8Mal Genetic Background: involves: C57BL/6
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat2^tm2Wz/Lat2^tm2Wz,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: C57BL/6
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gckr^tm1Jfg/Gckr^tm1Jfg Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0002499	chronic inflammation	"persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0002619	abnormal lymphocyte morphology/development	"anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lat^{tm8.1(CD2)Mal}/Lat^{tm8.1(CD2)Mal} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0002723	abnormal immune serum protein physiology	"abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003790	absent CD4+8- cells	"lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: B2m^tm1Unc/B2m^tm1Unc,H2-Ab1^tm1Doi/H2-Ab1^tm1Doi,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas Allelic Composition: Cd3e^tm1Mal/Cd3e^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003850	abnormal thymocyte activation/response	"anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0003944	abnormal T cell subpopulation ratio	"deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov,Lat2^tm1Wz/Lat2^tm1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004797	increased anti-erythrocyte antigen antibody level	"elevated level of antibodies to erythrocyte antigen present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0004827	increased susceptibility to autoimmune hemolytic anemia	"greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0004829	increased anti-chromatin antibody level	"increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0004917	abnormal T cell selection	"any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation" [GO:0045058]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0004946	abnormal regulatory T cell physiology	"any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004974	decreased regulatory T cell number	"reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lat^tm2.1Lov/Lat^tm2.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lat^tm2Mal/Lat^tm2Mal,Rag1^tm1Bal/Rag1^tm1Bal Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^{tm8.1(CD2)Mal}/Lat^{tm8.1(CD2)Mal} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm1Les/Lat^tm1Les,Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005094	abnormal T cell proliferation	"anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Flvcr1^tm1.1Jlab/Flvcr1^tm1.1Jlab Genetic Background: B6.129S4-Flvcr1^tm1.1Jlab
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005466	abnormal T helper 2 physiology	"anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm1Mal/Lat^tm6(DTR)Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm6(DTR)Mal/Lat^tm6(DTR)Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Il4^tm1Lky/Il4⁺,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm4Mal/Lat^tm6(DTR)Mal Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008037	abnormal T cell morphology	"any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syt1^tm4Sud/Syt1^tm4Sud Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008049	increased memory T cell number	"greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008070	absent T cells	"absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.2Wz Genetic Background: involves: C57BL/6 * FVB/N
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lat^tm1Les/Lat^tm1Les Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0008081	abnormal single-positive T cell number	"anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0008090	increased T-helper 2 cell number	"greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm8Mal/Lat^tm8Mal Genetic Background: involves: C57BL/6
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0008344	abnormal mature gamma-delta T cell morphology	"any structural anomaly of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Lat^tm1Les/Lat^tm1.1Wz,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0008353	increased mature gamma-delta T cell number	"increased number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas
MP:0008355	absent mature gamma-delta T cells	"absence of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0008356	abnormal gamma-delta T cell differentiation	"atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0008481	increased spleen germinal center number	"greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008499	increased IgG1 level	"greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm1.1Lov/Lat^tm1.1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008522	abnormal lymph node germinal center	"any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008555	abnormal interferon secretion	"anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Lat^tm6(DTR)Mal/Lat^tm6(DTR)Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008568	abnormal interleukin secretion	"anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0008660	increased interleukin-10 secretion	"increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Lat^tm2Mal/Lat^tm2Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm1Les/Lat^tm1Les,Tg(CD2-LAT2)1Wz/0 Genetic Background: Not Specified Allelic Composition: Lat^tm4Mal/Lat^tm4Mal,Tg(LckF505)3073Rmp/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008757	abnormal T cell receptor gamma chain V-J recombination	"any anomaly in the process by which V and J gene segments of the T cell receptor gamma chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^{tm8.1(CD2)Mal}/Lat^{tm8.1(CD2)Mal} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008759	abnormal T cell receptor delta chain V(D)J recombination	"any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^{tm8.1(CD2)Mal}/Lat^{tm8.1(CD2)Mal} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0008827	abnormal thymus cell ratio	"deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0008828	abnormal lymph node cell ratio	"deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Lat^tm3Mal/Lat^tm3Mal Genetic Background: involves: 129S2/SvPas Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd
MP:0009446	abnormal platelet dense granule physiology	"any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lat^tm2Mal/Lat^tm2Mal,Rag1^tm1Bal/Rag1^tm1Bal Genetic Background: involves: 129S2/SvPas * 129S4/SvJae Allelic Composition: Lat^tm1Mal/Lat^tm1Mal,Rag1^tm1Bal/Rag1^tm1Bal Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
MP:0009548	abnormal platelet aggregation	"any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]	Show Allelic Composition: Lat^tm1Bpay/Lat^tm1Bpay Genetic Background: involves: 129S2/SvPas
MP:0009549	impaired platelet aggregation	"decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]	Show Allelic Composition: Lat^tm4Mal/Lat^tm4Mal Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lat^tm2Mal/Lat^tm2Mal,Rag1^tm1Bal/Rag1^tm1Bal Genetic Background: involves: 129S2/SvPas * 129S4/SvJae Allelic Composition: Lat^tm1Mal/Lat^tm1Mal,Rag1^tm1Bal/Rag1^tm1Bal Genetic Background: involves: 129S2/SvPas * 129S4/SvJae
MP:0020519	renal glomerular immunoglobulin deposits	"any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002033	Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*	/ reaction
ENSMUSG00000005763	Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*	/ reaction
ENSMUSG00000034116	Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*	/ reaction / complex
ENSMUSG00000016933	Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*	/ reaction / complex
ENSMUSG00000020395	Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*	/ complex / reaction
ENSMUSG00000026117	Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*	/ reaction
ENSMUSG00000023274	Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*	/ reaction
ENSMUSG00000022781	Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*	/ complex / reaction
ENSMUSG00000036594	H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...	/ reaction
ENSMUSG00000031264	Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*	/ complex / reaction
ENSMUSG00000032094	Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*	/ reaction
ENSMUSG00000073421	H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...	/ reaction
ENSMUSG00000002699	Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*	/ complex / reaction
ENSMUSG00000034330	Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*	/ complex / reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ complex / reaction
ENSMUSG00000033721	Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*	/ reaction / complex
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ reaction / complex
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ complex / reaction
ENSMUSG00000030742	Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*	/ reaction
ENSMUSG00000009621	Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*	/ reaction / complex
ENSMUSG00000042626	Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	/ reaction / complex
ENSMUSG00000042351	Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*	/ reaction / complex
ENSMUSG00000030774	Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*	/ complex / reaction
ENSMUSG00000067341	H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*	/ reaction
ENSMUSG00000021457	Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*	/ reaction
ENSMUSG00000000409	Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*	/ reaction
ENSMUSG00000060586	H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*	/ reaction
ENSMUSG00000032093	Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*	/ reaction

1 s.

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