ENSMUSG00000005763


Mus musculus

Features
Gene ID: ENSMUSG00000005763
  
Biological name :Cd247
  
Synonyms : Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain
  
Possible biological names infered from orthology : CD247 molecule / P20963
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.3
Gene start: 165788681
Gene end: 165877277
  
Corresponding Affymetrix probe sets: 10351353 (MoGene1.0st)   1420716_at (Mouse Genome 430 2.0 Array)   1426079_at (Mouse Genome 430 2.0 Array)   1426396_at (Mouse Genome 430 2.0 Array)   1452539_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140926
Ensembl peptide - ENSMUSP00000124299
Ensembl peptide - ENSMUSP00000136456
Ensembl peptide - ENSMUSP00000005907
Ensembl peptide - ENSMUSP00000027849
Ensembl peptide - ENSMUSP00000083165
Ensembl peptide - ENSMUSP00000124297
NCBI entrez gene - 12503     See in Manteia.
MGI - MGI:88334
RefSeq - XM_017313285
RefSeq - NM_001113391
RefSeq - NM_001113392
RefSeq - NM_001113393
RefSeq - NM_031162
RefSeq - XM_011238745
RefSeq - XM_011238746
RefSeq Peptide - NP_001106863
RefSeq Peptide - NP_001106864
RefSeq Peptide - NP_112439
RefSeq Peptide - NP_001106862
swissprot - P24161
swissprot - Q3UU54
swissprot - J3QMU3
swissprot - A2MZG6
Ensembl - ENSMUSG00000005763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd247lENSDARG00000077240Danio rerio
 CD247ENSGALG00000015441Gallus gallus
 CD247ENSG00000198821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR021663  T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit
 IPR024128  T-cell surface glycoprotein CD3 zeta subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0070207 protein homotrimerization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042101 T cell receptor complex IEA
 cellular_componentGO:0042105 alpha-beta T cell receptor complex IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Id3tm1Zhu/Id3tm1Zhu
Genetic Background: B6.129S4-Id3tm1Zhu

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Id3tm1Zhu/Id3tm1Zhu
Genetic Background: B6.129S4-Id3tm1Zhu

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: involves: C57BL/6

 MP:0002433 abnormal T helper 1 morphology/development "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov
Genetic Background: B6.129S4-Cd247tm1Lov/J

 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mitfmi-tg/Mitf+
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: involves: C57BL/6

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov
Genetic Background: B6.129S4-Cd247tm1Lov/J

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mitfmi-tg/Mitf+
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: involves: C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fstl1tm2.1(cre/ERT2)Mvdh/Fstl1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: involves: C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Mitfmi-tg/Mitf+
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0008081 abnormal single-positive T cell number "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0008352 absent gamma-delta intraepithelial T cell "absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
Show

Allelic Composition: Spta1sph-2Bc/Spta1sph-2Bc
Genetic Background: involves: SELH

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008356 abnormal gamma-delta T cell differentiation "atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov
Genetic Background: B6.129S4-Cd247tm1Lov/J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mitfmi-tg/Mitf+
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008894 abnormal intraepithelial T cell morphology "any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov
Genetic Background: Not Specified

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Mitfmi-tg/Mitf+
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012726 abnormal uterine spiral artery morphology "any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)" [MGI:anna]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012727 abnormal uterine spiral artery remodeling "any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [MGI:anna]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cd247tm1Tks/Cd247tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013593 enlarged thymus cortex "increased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Cd247tm1Mhu/Cd247tm1Mhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000053977 Cd8a / P01731 / T-cell surface glycoprotein CD8 alpha chain / P01732* / CD8a molecule*  / complex
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex / reaction
 ENSMUSG00000053044 Cd8b1 / P10300 / T-cell surface glycoprotein CD8 beta chain / CD8B* / CD8B2* / P10966* / CD8b molecule* / CD8b2 molecule*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000028076 Cd1d1 / CD1D* / P15813* / CD1d molecule*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / complex / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / complex / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr