ENSMUSG00000053977


Mus musculus

Features
Gene ID: ENSMUSG00000053977
  
Biological name :Cd8a
  
Synonyms : Cd8a / P01731 / T-cell surface glycoprotein CD8 alpha chain
  
Possible biological names infered from orthology : CD8a molecule / P01732
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 71373427
Gene end: 71379173
  
Corresponding Affymetrix probe sets: 10538993 (MoGene1.0st)   1425335_at (Mouse Genome 430 2.0 Array)   1440164_x_at (Mouse Genome 430 2.0 Array)   1440811_x_at (Mouse Genome 430 2.0 Array)   1444078_at (Mouse Genome 430 2.0 Array)   1451673_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068123
Ensembl peptide - ENSMUSP00000131873
NCBI entrez gene - 12525     See in Manteia.
MGI - MGI:88346
RefSeq - NM_009857
RefSeq - NM_001081110
RefSeq Peptide - NP_001074579
RefSeq Peptide - NP_033987
swissprot - P01731
swissprot - Q8CAX3
Ensembl - ENSMUSG00000053977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD8AENSG00000153563Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR015468  CD8 alpha subunit
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002456 T cell mediated immunity IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0045065 cytotoxic T cell differentiation IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0051607 defense response to virus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044853 plasma membrane raft ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: PL.129S2(B6)-Cd8atm1Mak/Rdgz

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm2.1Welm/Cd8a+
Genetic Background: involves: 129P2/OlaHsd * AKR.1 * C57BL/6

Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd8atm2.1Welm/Cd8atm2.1Welm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htttm1Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Cd8atm1.1Welm/Cd8atm1.1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8a+
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pstpip2Lupo/Pstpip2Lupo,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: PL.129S2(B6)-Cd8atm1Mak/Rdgz

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd8am1Btlr/Cd8am1Btlr
Genetic Background: C57BL/6J-Cd8am1Btlr

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm1Asin/Cd8atm1Mak
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcdh15m4Btlr/Pcdh15m4Btlr
Genetic Background: C57BL/6J-Pcdh15m4Btlr

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Mak
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd8atm1.1Litt/Cd8atm1.1Litt
Genetic Background: either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd8atm2.1Welm/Cd8atm2.1Welm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm2.1Welm/Cd8atm2.1Welm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd8am1Btlr/Cd8am1Btlr
Genetic Background: C57BL/6J-Cd8am1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Mak
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm2Welm/Cd8atm2Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd8atm2.1Welm/Cd8atm2.1Welm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd8am1Btlr/Cd8am1Btlr
Genetic Background: C57BL/6J-Cd8am1Btlr

 MP:0008345 abnormal gamma-delta T cell number "anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008349 abnormal gamma-delta intraepithelial T cell morphology "any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0011822 increased CD8-positive, alpha-beta memory T cell proliferation "increase in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
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Allelic Composition: Pcdh15m4Btlr/Pcdh15m4Btlr
Genetic Background: C57BL/6J-Pcdh15m4Btlr

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex
 ENSMUSG00000053044 Cd8b1 / P10300 / T-cell surface glycoprotein CD8 beta chain / CD8B* / CD8B2* / P10966* / CD8b molecule* / CD8b2 molecule*  / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex






 

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