ENSG00000153563


Homo sapiens

Features
Gene ID: ENSG00000153563
  
Biological name :CD8A
  
Synonyms : CD8A / CD8a molecule / P01732
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p11.2
Gene start: 86784610
Gene end: 86808396
  
Corresponding Affymetrix probe sets: 205758_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387314
Ensembl peptide - ENSP00000283635
Ensembl peptide - ENSP00000321631
Ensembl peptide - ENSP00000386559
NCBI entrez gene - 925     See in Manteia.
OMIM - 186910
RefSeq - NM_001145873
RefSeq - NM_001768
RefSeq - NM_171827
RefSeq Peptide - NP_001139345
RefSeq Peptide - NP_001759
RefSeq Peptide - NP_741969
swissprot - P01732
swissprot - B8ZZZ4
Ensembl - ENSG00000153563
  
Related genetic diseases (OMIM): 608957 - CD8 deficiency, familial, 608957
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cd8aENSMUSG00000053977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR015468  CD8 alpha subunit
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002456 T cell mediated immunity IBA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0019882 antigen processing and presentation NAS
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0045065 cytotoxic T cell differentiation IBA
 biological_processGO:0050776 regulation of immune response TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042101 T cell receptor complex NAS
 cellular_componentGO:0044853 plasma membrane raft IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity NAS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042288 MHC class I protein binding NAS


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0002110 Bronchiectasis 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002718 Recurrent bacterial infections 
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 HP:0003577 Onset at birth 
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 HP:0004429 Recurrent viral infections 
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 HP:0005422 Isolated absence of CD8+ T cells 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex
 ENSG00000172116 CD8B / P10966 / CD8b molecule  / complex
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / complex
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / complex






 

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