ENSG00000172116


Homo sapiens

Features
Gene ID: ENSG00000172116
  
Biological name :CD8B
  
Synonyms : CD8B / CD8b molecule / P10966
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p11.2
Gene start: 86815339
Gene end: 86861924
  
Corresponding Affymetrix probe sets: 1553562_at (Human Genome U133 Plus 2.0 Array)   207979_s_at (Human Genome U133 Plus 2.0 Array)   215332_s_at (Human Genome U133 Plus 2.0 Array)   230037_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377358
Ensembl peptide - ENSP00000377356
Ensembl peptide - ENSP00000394806
Ensembl peptide - ENSP00000331172
Ensembl peptide - ENSP00000340592
Ensembl peptide - ENSP00000375070
NCBI entrez gene - 926     See in Manteia.
OMIM - 186730
RefSeq - XM_011533164
RefSeq - NM_001178100
RefSeq - NM_004931
RefSeq - NM_172101
RefSeq - NM_172102
RefSeq - NM_172213
RefSeq Peptide - NP_001171571
RefSeq Peptide - NP_004922
RefSeq Peptide - NP_742099
RefSeq Peptide - NP_742100
RefSeq Peptide - NP_757362
swissprot - P10966
swissprot - E9PD41
Ensembl - ENSG00000172116
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD8BENSGALG00000015902Gallus gallus
 Cd8b1ENSMUSG00000053044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD8B2 / CD8b2 moleculeENSG0000025412684


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0050776 regulation of immune response TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042101 T cell receptor complex NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity NAS
 molecular_functionGO:0042288 MHC class I protein binding NAS


Pathways (from Reactome)
Pathway description
Nef Mediated CD8 Down-regulation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000153563 CD8A / P01732 / CD8a molecule  / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / complex
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / complex
 ENSG00000047249 Q9UI12 / ATP6V1H / ATPase H+ transporting V1 subunit H  / complex / reaction






 

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