ENSG00000006125


Homo sapiens

Features
Gene ID: ENSG00000006125
  
Biological name :AP2B1
  
Synonyms : adaptor related protein complex 2 beta 1 subunit / AP2B1 / P63010
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 35578046
Gene end: 35726409
  
Corresponding Affymetrix probe sets: 200612_s_at (Human Genome U133 Plus 2.0 Array)   200615_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481246
Ensembl peptide - ENSP00000487324
Ensembl peptide - ENSP00000484708
Ensembl peptide - ENSP00000483185
Ensembl peptide - ENSP00000482835
Ensembl peptide - ENSP00000482825
Ensembl peptide - ENSP00000482315
Ensembl peptide - ENSP00000481704
Ensembl peptide - ENSP00000464966
Ensembl peptide - ENSP00000465357
Ensembl peptide - ENSP00000465848
Ensembl peptide - ENSP00000466580
Ensembl peptide - ENSP00000466812
Ensembl peptide - ENSP00000467382
Ensembl peptide - ENSP00000468183
Ensembl peptide - ENSP00000468813
Ensembl peptide - ENSP00000478115
Ensembl peptide - ENSP00000478471
Ensembl peptide - ENSP00000479691
NCBI entrez gene - 163     See in Manteia.
OMIM - 601025
RefSeq - XM_005257938
RefSeq - XM_017024286
RefSeq - XM_017024285
RefSeq - XM_017024284
RefSeq - XM_011524455
RefSeq - XM_011524454
RefSeq - XM_011524453
RefSeq - XM_011524452
RefSeq - XM_011524451
RefSeq - XM_011524450
RefSeq - XM_011524449
RefSeq - NM_001030006
RefSeq - NM_001282
RefSeq - XM_017024287
RefSeq - XM_011524448
RefSeq - XM_005257937
RefSeq - XM_005257941
RefSeq Peptide - NP_001273
RefSeq Peptide - NP_001025177
swissprot - P63010
swissprot - A0A140VJE8
swissprot - K7ERB2
swissprot - K7EN71
swissprot - K7EMN7
swissprot - K7EKZ5
swissprot - K7EJX1
swissprot - K7EJ01
swissprot - A0A087WU93
swissprot - A0A087WXS3
swissprot - A0A087WYD1
swissprot - A0A087WZQ6
swissprot - A0A087X253
Ensembl - ENSG00000006125
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2b1ENSDARG00000035152Danio rerio
 AP2B1ENSGALG00000042125Gallus gallus
 Ap2b1ENSMUSG00000035152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunitENSG0000010028083
AP4B1 / Q9Y6B7 / adaptor related protein complex 4 beta 1 subunitENSG0000013426223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072583 clathrin-dependent endocytosis TAS
 biological_processGO:0099590 neurotransmitter receptor internalization IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1905477 positive regulation of protein localization to membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030118 clathrin coat IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IMP
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 molecular_functionGO:0005048 signal sequence binding TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030276 clathrin binding TAS
 molecular_functionGO:0035615 clathrin adaptor activity TAS


Pathways (from Reactome)
Pathway description
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / reaction / complex
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / reaction / complex
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000172116 CD8B / P10966 / CD8b molecule  / complex / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000047249 Q9UI12 / ATP6V1H / ATPase H+ transporting V1 subunit H  / reaction / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / reaction / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / reaction / complex
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex / reaction
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000169174 PCSK9 / Q8NBP7 / proprotein convertase subtilisin/kexin type 9  / reaction / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / reaction / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000130164 LDLR / P01130 / low density lipoprotein receptor  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr