ENSG00000100151


Homo sapiens

Features
Gene ID: ENSG00000100151
  
Biological name :PICK1
  
Synonyms : PICK1 / protein interacting with PRKCA 1 / Q9NRD5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 38056311
Gene end: 38075701
  
Corresponding Affymetrix probe sets: 204746_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410793
Ensembl peptide - ENSP00000398141
Ensembl peptide - ENSP00000413962
Ensembl peptide - ENSP00000416487
Ensembl peptide - ENSP00000349465
Ensembl peptide - ENSP00000385205
Ensembl peptide - ENSP00000387861
Ensembl peptide - ENSP00000397588
NCBI entrez gene - 9463     See in Manteia.
OMIM - 605926
RefSeq - XM_017029095
RefSeq - NM_001039584
RefSeq - NM_012407
RefSeq - XM_006724379
RefSeq - XM_006724380
RefSeq - XM_011530517
RefSeq - XM_017029090
RefSeq - XM_017029091
RefSeq - XM_017029092
RefSeq - XM_017029093
RefSeq - XM_017029094
RefSeq - NM_001039583
RefSeq Peptide - NP_001034673
RefSeq Peptide - NP_036539
RefSeq Peptide - NP_001034672
swissprot - F6V3V1
swissprot - F6VY12
swissprot - E7EX80
swissprot - Q9NRD5
swissprot - A0A024R1J5
swissprot - F6TII1
swissprot - F6V107
Ensembl - ENSG00000100151
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pick1ENSDARG00000071152Danio rerio
 PICK1ENSGALG00000041823Gallus gallus
 Pick1ENSMUSG00000068206Mus musculus
 Pick1ENSMUSG00000116121Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR010504  Arfaptin homology (AH) domain
 IPR027267  AH/BAR domain superfamily
 IPR030798  Arfaptin family
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0015844 monoamine transport IDA
 biological_processGO:0021782 glial cell development ISS
 biological_processGO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IBA
 biological_processGO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation ISS
 biological_processGO:0036294 cellular response to decreased oxygen levels ISS
 biological_processGO:0042149 cellular response to glucose starvation ISS
 biological_processGO:0043045 DNA methylation involved in embryo development NAS
 biological_processGO:0043046 DNA methylation involved in gamete generation TAS
 biological_processGO:0043113 receptor clustering ISS
 biological_processGO:0045161 neuronal ion channel clustering TAS
 biological_processGO:0060292 long term synaptic depression ISS
 biological_processGO:0097061 dendritic spine organization ISS
 biological_processGO:0097062 dendritic spine maintenance ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0001664 G-protein coupled receptor binding ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005080 protein kinase C binding ISS
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISS
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding ISS
 molecular_functionGO:0071933 Arp2/3 complex binding ISS


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Trafficking of GluR2-containing AMPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000156298 P41732 / TSPAN7 / tetraspanin 7  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction






 

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