ENSG00000152578


Homo sapiens

Features
Gene ID: ENSG00000152578
  
Biological name :GRIA4
  
Synonyms : glutamate ionotropic receptor AMPA type subunit 4 / GRIA4 / P48058
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.3
Gene start: 105609994
Gene end: 105982092
  
Corresponding Affymetrix probe sets: 1569178_at (Human Genome U133 Plus 2.0 Array)   208464_at (Human Genome U133 Plus 2.0 Array)   238663_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433873
Ensembl peptide - ENSP00000433621
Ensembl peptide - ENSP00000435775
Ensembl peptide - ENSP00000436449
Ensembl peptide - ENSP00000436143
Ensembl peptide - ENSP00000282499
Ensembl peptide - ENSP00000376833
Ensembl peptide - ENSP00000376835
Ensembl peptide - ENSP00000415551
Ensembl peptide - ENSP00000432180
Ensembl peptide - ENSP00000432371
Ensembl peptide - ENSP00000432443
NCBI entrez gene - 2893     See in Manteia.
OMIM - 138246
RefSeq - XM_017017611
RefSeq - NM_001077243
RefSeq - NM_001077244
RefSeq - NM_001112812
RefSeq - XM_005271518
RefSeq - XM_006718823
RefSeq - XM_011542775
RefSeq - XM_011542776
RefSeq - XM_011542777
RefSeq - XM_017017609
RefSeq - XM_017017610
RefSeq - NM_000829
RefSeq Peptide - NP_001070711
RefSeq Peptide - NP_001070712
RefSeq Peptide - NP_001106283
RefSeq Peptide - NP_000820
swissprot - E9PJZ5
swissprot - E9PR13
swissprot - P48058
swissprot - E9PQY1
swissprot - G3V164
swissprot - H0YDL4
Ensembl - ENSG00000152578
  
Related genetic diseases (OMIM): 617864 - Neurodevelopmental disorder with or without seizures and gait abnormalities, 617864
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRIA4ENSGALG00000038995Gallus gallus
 Gria4ENSMUSG00000025892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025171
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567570
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551166
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441837
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118937
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387336
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940334
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573733
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277127
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220826
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150922
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307921
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546421
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603220
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688420
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007215 glutamate receptor signaling pathway TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005231 excitatory extracellular ligand-gated ion channel activity TAS
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction / complex
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction / complex
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / reaction / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction / complex
 ENSG00000277586 NEFL / P07196 / neurofilament light  / reaction
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / reaction
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction






 

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