ENSG00000105737


Homo sapiens

Features
Gene ID: ENSG00000105737
  
Biological name :GRIK5
  
Synonyms : glutamate ionotropic receptor kainate type subunit 5 / GRIK5 / Q16478
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 41998321
Gene end: 42069498
  
Corresponding Affymetrix probe sets: 1553168_at (Human Genome U133 Plus 2.0 Array)   214966_at (Human Genome U133 Plus 2.0 Array)   217509_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262895
Ensembl peptide - ENSP00000301218
Ensembl peptide - ENSP00000469135
Ensembl peptide - ENSP00000470251
NCBI entrez gene - 2901     See in Manteia.
OMIM - 600283
RefSeq - XM_017026713
RefSeq - NM_001301030
RefSeq - NM_002088
RefSeq - XM_011526865
RefSeq - XM_011526867
RefSeq - XM_011526868
RefSeq - XM_011526869
RefSeq - XM_005258821
RefSeq - XM_011526862
RefSeq - XM_011526863
RefSeq Peptide - NP_001287959
RefSeq Peptide - NP_002079
swissprot - Q16478
swissprot - M0QXF6
Ensembl - ENSG00000105737
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grik5ENSDARG00000101449Danio rerio
 si:ch211-264f5.8ENSDARG00000078151Danio rerio
 Grik5ENSMUSG00000003378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940364
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441840
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118939
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387338
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257831
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551131
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025131
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567531
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277123
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220822
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688420
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546420
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345419
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307919
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150918
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878518
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006621 protein retention in ER lumen IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0051649 establishment of localization in cell IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032983 kainate selective glutamate receptor complex IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0008066 glutamate receptor activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015277 kainate selective glutamate receptor activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171189 GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1  / complex
 ENSG00000164418 GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2  / complex
 ENSG00000105737 GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5  / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex






 

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