ENSG00000161509


Homo sapiens

Features
Gene ID: ENSG00000161509
  
Biological name :GRIN2C
  
Synonyms : glutamate ionotropic receptor NMDA type subunit 2C / GRIN2C / Q14957
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 74842023
Gene end: 74861504
  
Corresponding Affymetrix probe sets: 1569268_at (Human Genome U133 Plus 2.0 Array)   210400_at (Human Genome U133 Plus 2.0 Array)   217573_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000293190
Ensembl peptide - ENSP00000338645
NCBI entrez gene - 2905     See in Manteia.
OMIM - 138254
RefSeq - XM_017024544
RefSeq - NM_000835
RefSeq - NM_001278553
RefSeq - XM_011524687
RefSeq - XM_011524688
RefSeq - XM_011524689
RefSeq - XM_011524692
RefSeq - XM_006721845
RefSeq - XM_006721846
RefSeq - XM_011524686
RefSeq Peptide - NP_000826
RefSeq Peptide - NP_001265482
swissprot - Q14957
swissprot - H0Y2V8
Ensembl - ENSG00000161509
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grin2caENSDARG00000078149Danio rerio
 grin2cbENSDARG00000077560Danio rerio
 GRIN2CENSGALG00000027415Gallus gallus
 Grin2cENSMUSG00000020734Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546449
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345445
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307943
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603221
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878519
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688417
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551116
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257816
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220815
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940315
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025115
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387315
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567515
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573715
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441814
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118914
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277114


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR018884  Glutamate [NMDA] receptor, epsilon subunit, C-terminal
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007215 glutamate receptor signaling pathway TAS
 biological_processGO:0007420 brain development NAS
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033058 directional locomotion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0048167 regulation of synaptic plasticity NAS
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0097553 calcium ion transmembrane import into cytosol IDA
 biological_processGO:0098976 excitatory chemical synaptic transmission NAS
 biological_processGO:1903539 protein localization to postsynaptic membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004972 NMDA glutamate receptor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022849 glutamate-gated calcium ion channel activity IDA


Pathways (from Reactome)
Pathway description
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / complex
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / reaction / complex
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / complex / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000163110 PDLIM5 / Q96HC4 / PDZ and LIM domain 5  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction / complex
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction / complex
 ENSG00000156564 LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2  / complex / reaction
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / complex
 ENSG00000183092 BEGAIN / Q9BUH8 / brain enriched guanylate kinase associated  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex
 ENSG00000197555 O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1  / complex / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr