ENSG00000163110


Homo sapiens

Features
Gene ID: ENSG00000163110
  
Biological name :PDLIM5
  
Synonyms : PDLIM5 / PDZ and LIM domain 5 / Q96HC4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.3
Gene start: 94451857
Gene end: 94668227
  
Corresponding Affymetrix probe sets: 203242_s_at (Human Genome U133 Plus 2.0 Array)   203243_s_at (Human Genome U133 Plus 2.0 Array)   211680_at (Human Genome U133 Plus 2.0 Array)   211681_s_at (Human Genome U133 Plus 2.0 Array)   212412_at (Human Genome U133 Plus 2.0 Array)   213684_s_at (Human Genome U133 Plus 2.0 Array)   216803_at (Human Genome U133 Plus 2.0 Array)   216804_s_at (Human Genome U133 Plus 2.0 Array)   221994_at (Human Genome U133 Plus 2.0 Array)   241208_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426804
Ensembl peptide - ENSP00000426379
Ensembl peptide - ENSP00000429577
Ensembl peptide - ENSP00000486938
Ensembl peptide - ENSP00000486834
Ensembl peptide - ENSP00000480359
Ensembl peptide - ENSP00000442187
Ensembl peptide - ENSP00000321746
Ensembl peptide - ENSP00000322021
Ensembl peptide - ENSP00000352210
Ensembl peptide - ENSP00000369527
Ensembl peptide - ENSP00000398469
Ensembl peptide - ENSP00000422528
Ensembl peptide - ENSP00000422833
Ensembl peptide - ENSP00000423009
Ensembl peptide - ENSP00000424297
Ensembl peptide - ENSP00000424360
NCBI entrez gene - 10611     See in Manteia.
OMIM - 605904
RefSeq - XM_017007658
RefSeq - NM_001011515
RefSeq - NM_001011516
RefSeq - NM_001256425
RefSeq - NM_001256426
RefSeq - NM_001256427
RefSeq - NM_001256428
RefSeq - NM_001256429
RefSeq - NM_006457
RefSeq - XM_005262693
RefSeq - XM_005262695
RefSeq - XM_005262696
RefSeq - XM_005262698
RefSeq - XM_006714066
RefSeq - XM_006714068
RefSeq - XM_006714069
RefSeq - XM_006714070
RefSeq - XM_011531543
RefSeq - XM_017007657
RefSeq - NM_001011513
RefSeq Peptide - NP_001011515
RefSeq Peptide - NP_001011516
RefSeq Peptide - NP_001243354
RefSeq Peptide - NP_001243355
RefSeq Peptide - NP_001243356
RefSeq Peptide - NP_001243357
RefSeq Peptide - NP_001243358
RefSeq Peptide - NP_006448
RefSeq Peptide - NP_001011513
swissprot - A0A0A0MSP3
swissprot - D6RAA1
swissprot - A0A0D9SFW3
swissprot - A0A0D9SFR4
swissprot - H0Y8Y3
swissprot - H0Y929
swissprot - H0YBI4
swissprot - D6RGG6
swissprot - Q96HC4
Ensembl - ENSG00000163110
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdlim5aENSDARG00000101777Danio rerio
 pdlim5bENSDARG00000027600Danio rerio
 PDLIM5ENSGALG00000012211Gallus gallus
 Pdlim5ENSMUSG00000028273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LDB3 / O75112 / LIM domain binding 3ENSG0000012236737
PDLIM7 / Q9NR12 / PDZ and LIM domain 7ENSG0000019692335
PXN / P49023 / paxillinENSG0000008915916
O43294 / TGFB1I1 / transforming growth factor beta 1 induced transcript 1ENSG0000014068216
LPXN / O60711 / leupaxinENSG0000011003114
LIMS1 / P48059 / LIM zinc finger domain containing 1ENSG0000016975614
LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2ENSG0000007216313
FHL3 / Q13643 / four and a half LIM domains 3ENSG0000018338612
FHL2 / Q14192 / four and a half LIM domains 2ENSG0000011564111
FHL5 / Q5TD97 / four and a half LIM domains 5ENSG0000011221411
FHL1 / Q13642 / four and a half LIM domains 1ENSG000000222679
AC112229.3ENSG000002572075
AC013271.1ENSG000002843375
LIMS4 / P0CW20 / LIM zinc finger domain containing 4ENSG000002566712
LIMS3 / P0CW19 / LIM zinc finger domain containing 3ENSG000002569772


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000197555 O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1  / complex / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex






 

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