ENSG00000169756


Homo sapiens

Features
Gene ID: ENSG00000169756
  
Biological name :LIMS1
  
Synonyms : LIMS1 / LIM zinc finger domain containing 1 / P48059
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.3
Gene start: 108534355
Gene end: 108687246
  
Corresponding Affymetrix probe sets: 1566129_at (Human Genome U133 Plus 2.0 Array)   1570259_at (Human Genome U133 Plus 2.0 Array)   207198_s_at (Human Genome U133 Plus 2.0 Array)   212687_at (Human Genome U133 Plus 2.0 Array)   223800_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410751
Ensembl peptide - ENSP00000402322
Ensembl peptide - ENSP00000437912
Ensembl peptide - ENSP00000446121
Ensembl peptide - ENSP00000331775
Ensembl peptide - ENSP00000337598
Ensembl peptide - ENSP00000376987
Ensembl peptide - ENSP00000386926
Ensembl peptide - ENSP00000387264
Ensembl peptide - ENSP00000390862
Ensembl peptide - ENSP00000399267
NCBI entrez gene - 3987     See in Manteia.
OMIM - 602567
RefSeq - XM_017004096
RefSeq - NM_001193485
RefSeq - NM_001193488
RefSeq - NM_004987
RefSeq - XM_005263946
RefSeq - XM_005263948
RefSeq - XM_005263949
RefSeq - XM_005263950
RefSeq - XM_005263951
RefSeq - XM_017004091
RefSeq - XM_017004092
RefSeq - XM_017004093
RefSeq - XM_017004094
RefSeq - NM_001193482
RefSeq - NM_001193483
RefSeq - NM_001193484
RefSeq Peptide - NP_001180412
RefSeq Peptide - NP_001180413
RefSeq Peptide - NP_001180414
RefSeq Peptide - NP_001180417
RefSeq Peptide - NP_004978
RefSeq Peptide - NP_001180411
swissprot - A0A0M3HER1
swissprot - F8WB59
swissprot - F8WC86
swissprot - F8WE10
swissprot - C9JF46
swissprot - P48059
Ensembl - ENSG00000169756
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lims1ENSDARG00000026985Danio rerio
 lims2ENSDARG00000014976Danio rerio
 Lims1ENSMUSG00000019920Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2ENSG0000007216374
AC112229.3ENSG0000025720760
AC013271.1ENSG0000028433760
LIMS3 / P0CW19 / LIM zinc finger domain containing 3ENSG0000025697729
LIMS4 / P0CW20 / LIM zinc finger domain containing 4ENSG0000025667129
PDLIM5 / Q96HC4 / PDZ and LIM domain 5ENSG0000016311022
LDB3 / O75112 / LIM domain binding 3ENSG0000012236720
PDLIM7 / Q9NR12 / PDZ and LIM domain 7ENSG0000019692320
PXN / P49023 / paxillinENSG0000008915919
FHL3 / Q13643 / four and a half LIM domains 3ENSG0000018338619
FHL1 / Q13642 / four and a half LIM domains 1ENSG0000002226718
FHL2 / Q14192 / four and a half LIM domains 2ENSG0000011564118
O43294 / TGFB1I1 / transforming growth factor beta 1 induced transcript 1ENSG0000014068218
FHL5 / Q5TD97 / four and a half LIM domains 5ENSG0000011221417
LPXN / O60711 / leupaxinENSG0000011003115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR017351  LIM and senescent cell antigen-like-containing domain protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007569 cell aging TAS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0034329 cell junction assembly TAS
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IMP
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148484 RSU1 / Q15404 / Ras suppressor protein 1  / complex / reaction
 ENSG00000166333 ILK / Q13418 / integrin linked kinase  / complex






 

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