ENSG00000110031


Homo sapiens

Features
Gene ID: ENSG00000110031
  
Biological name :LPXN
  
Synonyms : leupaxin / LPXN / O60711
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.1
Gene start: 58526871
Gene end: 58578220
  
Corresponding Affymetrix probe sets: 216250_s_at (Human Genome U133 Plus 2.0 Array)   242778_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437094
Ensembl peptide - ENSP00000461855
Ensembl peptide - ENSP00000378512
Ensembl peptide - ENSP00000431284
NCBI entrez gene - 9404     See in Manteia.
OMIM - 605390
RefSeq - XM_017018579
RefSeq - XM_006718750
RefSeq - XM_011545388
RefSeq - XM_011545390
RefSeq - XM_011545391
RefSeq - XM_011545393
RefSeq - XM_011545394
RefSeq - NM_001143995
RefSeq - NM_001307951
RefSeq - NM_004811
RefSeq Peptide - NP_004802
RefSeq Peptide - NP_001137467
RefSeq Peptide - NP_001294880
swissprot - E9PNX9
swissprot - O60711
swissprot - B7Z5P7
Ensembl - ENSG00000110031
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpxnENSDARG00000079315Danio rerio
 LpxnENSMUSG00000024696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PXN / P49023 / paxillinENSG0000008915956
O43294 / TGFB1I1 / transforming growth factor beta 1 induced transcript 1ENSG0000014068247
PDLIM5 / Q96HC4 / PDZ and LIM domain 5ENSG0000016311023
LDB3 / O75112 / LIM domain binding 3ENSG0000012236722
PDLIM7 / Q9NR12 / PDZ and LIM domain 7ENSG0000019692320
FHL3 / Q13643 / four and a half LIM domains 3ENSG0000018338617
LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2ENSG0000007216315
FHL5 / Q5TD97 / four and a half LIM domains 5ENSG0000011221415
LIMS1 / P48059 / LIM zinc finger domain containing 1ENSG0000016975615
FHL2 / Q14192 / four and a half LIM domains 2ENSG0000011564114
FHL1 / Q13642 / four and a half LIM domains 1ENSG0000002226712
AC013271.1ENSG000002843375
AC112229.3ENSG000002572075
LIMS3 / P0CW19 / LIM zinc finger domain containing 3ENSG000002569771
LIMS4 / P0CW20 / LIM zinc finger domain containing 4ENSG000002566711


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR017305  Leupaxin/Paxillin/TGFB1I1
 IPR034961  Leupaxin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway IDA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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