ENSG00000115641


Homo sapiens

Features
Gene ID: ENSG00000115641
  
Biological name :FHL2
  
Synonyms : FHL2 / four and a half LIM domains 2 / Q14192
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q12.2
Gene start: 105357712
Gene end: 105438513
  
Corresponding Affymetrix probe sets: 202949_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397083
Ensembl peptide - ENSP00000386892
Ensembl peptide - ENSP00000414872
Ensembl peptide - ENSP00000476199
Ensembl peptide - ENSP00000433567
Ensembl peptide - ENSP00000322909
Ensembl peptide - ENSP00000344266
Ensembl peptide - ENSP00000350846
Ensembl peptide - ENSP00000377020
Ensembl peptide - ENSP00000377021
Ensembl peptide - ENSP00000386633
Ensembl peptide - ENSP00000386665
NCBI entrez gene - 2274     See in Manteia.
OMIM - 602633
RefSeq - NM_001450
RefSeq - NM_001039492
RefSeq - NM_001318894
RefSeq - NM_001318895
RefSeq - NM_001318896
RefSeq - NM_001318897
RefSeq - NM_001318898
RefSeq - NM_001318899
RefSeq - NM_201555
RefSeq - NM_201557
RefSeq - XM_011510798
RefSeq Peptide - NP_001305824
RefSeq Peptide - NP_001305825
RefSeq Peptide - NP_001305826
RefSeq Peptide - NP_001305827
RefSeq Peptide - NP_001305828
RefSeq Peptide - NP_001441
RefSeq Peptide - NP_963849
RefSeq Peptide - NP_963851
RefSeq Peptide - NP_001034581
RefSeq Peptide - NP_001305823
swissprot - C9J3S8
swissprot - A0A0A0MSG2
swissprot - Q6I9R8
swissprot - U3KQT4
swissprot - E9PKF4
swissprot - Q14192
swissprot - F8WDA8
swissprot - J3KNW4
Ensembl - ENSG00000115641
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhl2aENSDARG00000042018Danio rerio
 fhl2bENSDARG00000003991Danio rerio
 FHL2ENSGALG00000016797Gallus gallus
 Fhl2ENSMUSG00000008136Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FHL5 / Q5TD97 / four and a half LIM domains 5ENSG0000011221459
FHL3 / Q13643 / four and a half LIM domains 3ENSG0000018338653
FHL1 / Q13642 / four and a half LIM domains 1ENSG0000002226743
PXN / P49023 / paxillinENSG0000008915926
LDB3 / O75112 / LIM domain binding 3ENSG0000012236726
O43294 / TGFB1I1 / transforming growth factor beta 1 induced transcript 1ENSG0000014068225
LIMS1 / P48059 / LIM zinc finger domain containing 1ENSG0000016975625
PDLIM5 / Q96HC4 / PDZ and LIM domain 5ENSG0000016311025
PDLIM7 / Q9NR12 / PDZ and LIM domain 7ENSG0000019692324
LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2ENSG0000007216324
LPXN / O60711 / leupaxinENSG0000011003120
AC112229.3ENSG0000025720713
AC013271.1ENSG0000028433713
LIMS3 / P0CW19 / LIM zinc finger domain containing 3ENSG000002569772
LIMS4 / P0CW20 / LIM zinc finger domain containing 4ENSG000002566712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009725 response to hormone IMP
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0055014 atrial cardiac muscle cell development IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060347 heart trabecula formation IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031430 M band IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding NAS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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 HP:0000982 Palmoplantar keratoderma 
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 HP:0001644 Dilated cardiomyopathy 
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 HP:0001874 Abnormality of neutrophil 
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 HP:0003198 Myopathy 
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 HP:0003236 Elevated serum creatine phosphokinase 
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 HP:0003457 Abnormal EMG findings "Abnormal results of investigations using electromyography (EMG)." [HPO:curators]
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 HP:0100578 Lipoatrophy "Localized loss of fat tissue." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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