ENSG00000089159


Homo sapiens

Features
Gene ID: ENSG00000089159
  
Biological name :PXN
  
Synonyms : P49023 / paxillin / PXN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.23
Gene start: 120210439
Gene end: 120265771
  
Corresponding Affymetrix probe sets: 201087_at (Human Genome U133 Plus 2.0 Array)   211823_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446893
Ensembl peptide - ENSP00000446650
Ensembl peptide - ENSP00000447180
Ensembl peptide - ENSP00000490896
Ensembl peptide - ENSP00000490352
Ensembl peptide - ENSP00000489977
Ensembl peptide - ENSP00000489840
Ensembl peptide - ENSP00000228307
Ensembl peptide - ENSP00000267257
Ensembl peptide - ENSP00000391283
Ensembl peptide - ENSP00000395536
Ensembl peptide - ENSP00000443745
Ensembl peptide - ENSP00000443887
Ensembl peptide - ENSP00000446607
NCBI entrez gene - 5829     See in Manteia.
OMIM - 602505
RefSeq - XM_017019743
RefSeq - XM_017019726
RefSeq - XM_017019727
RefSeq - XM_017019728
RefSeq - XM_017019729
RefSeq - XM_017019730
RefSeq - XM_017019731
RefSeq - XM_017019733
RefSeq - XM_017019734
RefSeq - XM_017019735
RefSeq - XM_017019736
RefSeq - XM_017019737
RefSeq - XM_017019738
RefSeq - XM_017019739
RefSeq - XM_017019740
RefSeq - XM_017019741
RefSeq - XM_017019742
RefSeq - NM_001080855
RefSeq - NM_001243756
RefSeq - NM_002859
RefSeq - NM_025157
RefSeq - XM_005253917
RefSeq - XM_006719532
RefSeq - XM_006719534
RefSeq - XM_006719535
RefSeq - XM_006719536
RefSeq - XM_011538622
RefSeq - XM_011538623
RefSeq Peptide - NP_002850
RefSeq Peptide - NP_079433
RefSeq Peptide - NP_001074324
RefSeq Peptide - NP_001230685
swissprot - F5GZ78
swissprot - F5H836
swissprot - F8VZ39
swissprot - F8W0G0
swissprot - A0A1B0GWE7
swissprot - F8W1E0
swissprot - P49023
swissprot - A0A140VJQ8
swissprot - F8W0K8
swissprot - A0A1B0GV30
swissprot - A0A1B0GU60
swissprot - A0A1B0GTU4
Ensembl - ENSG00000089159
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pxnaENSDARG00000088590Danio rerio
 pxnbENSDARG00000060766Danio rerio
 PXNENSGALG00000007247Gallus gallus
 PxnENSMUSG00000029528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43294 / TGFB1I1 / transforming growth factor beta 1 induced transcript 1ENSG0000014068240
LPXN / O60711 / leupaxinENSG0000011003136
LDB3 / O75112 / LIM domain binding 3ENSG0000012236719
PDLIM7 / Q9NR12 / PDZ and LIM domain 7ENSG0000019692318
PDLIM5 / Q96HC4 / PDZ and LIM domain 5ENSG0000016311016
LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2ENSG0000007216313
FHL2 / Q14192 / four and a half LIM domains 2ENSG0000011564112
LIMS1 / P48059 / LIM zinc finger domain containing 1ENSG0000016975612
FHL3 / Q13643 / four and a half LIM domains 3ENSG0000018338611
FHL5 / Q5TD97 / four and a half LIM domains 5ENSG0000011221410
FHL1 / Q13642 / four and a half LIM domains 1ENSG000000222679
AC112229.3ENSG000002572074
AC013271.1ENSG000002843374
LIMS4 / P0CW20 / LIM zinc finger domain containing 4ENSG000002566710
LIMS3 / P0CW19 / LIM zinc finger domain containing 3ENSG000002569770


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR001904  Paxillin
 IPR017305  Leupaxin/Paxillin/TGFB1I1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007172 signal complex assembly TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IEP
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:1901652 response to peptide IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005875 microtubule associated complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0017166 vinculin binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0038191 neuropilin binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / complex
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction






 

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