ENSDARG00000060766


Danio rerio

Features
Gene ID: ENSDARG00000060766
  
Biological name :pxnb
  
Synonyms : paxillin b / pxnb
  
Possible biological names infered from orthology : P49023 / paxillin / PXN / Q8VI36
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 3496204
Gene end: 3519152
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080428
swissprot - E7F7U1
ZFIN ID - ZDB-GENE-130530-697
Ensembl - ENSDARG00000060766
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PXNENSGALG00000007247Gallus gallus
 PXNENSG00000089159Homo sapiens
 PxnENSMUSG00000029528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pxna / paxillin a / PXN* / P49023* / Q8VI36* / paxillin*ENSDARG0000008859073
lpxn / leupaxin / O60711* / Q99N69*ENSDARG0000007931534
pdlim5a / PDZ and LIM domain 5a / PDLIM5* / Q8CI51* / Q96HC4* / PDZ and LIM domain 5* / PDZ and LIM domain protein 5 *ENSDARG0000010177718
pdlim5b / PDZ and LIM domain 5b / PDLIM5* / Q96HC4* / PDZ and LIM domain 5*ENSDARG0000002760018
ldb3a / LIM domain binding 3a / LDB3* / O75112* / Q9JKS4* / LIM domain binding 3* / LIM domain-binding protein 3 *ENSDARG0000005632218
CABZ01078593.1 / Q3TJD7* / PDLIM7* / Q9NR12* / PDZ and LIM domain 7* / PDZ and LIM domain protein 7 *ENSDARG0000010385415
fhl2a / four and a half LIM domains 2a / FHL2* / O70433* / Q14192* / four and a half LIM domains 2* / Four and a half LIM domains protein 2 *ENSDARG0000004201813
fhl3a / four and a half LIM domains 3a / FHL3* / Q13643* / Q9R059* / four and a half LIM domains 3* / Four and a half LIM domains protein 3 *ENSDARG0000003464313
fhl2b / four and a half LIM domains 2b / FHL2* / O70433* / Q14192* / four and a half LIM domains 2* / Four and a half LIM domains protein 2 *ENSDARG0000000399113
lims1 / LIM and senescent cell antigen-like domains 1 / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / AC013271.1* / AC112229.3* / LIM zinc finger domain containing 4* / LIM zinc finger do...ENSDARG0000002698513
fhl5 / four and a half LIM domains 5 / Q5TD97* / Q9WTX7* / Four and a half LIM domains protein 5 *ENSDARG0000001480512
fhl3b / four and a half LIM domains 3b / FHL3* / Q13643* / Q9R059* / four and a half LIM domains 3* / Four and a half LIM domains protein 3 *ENSDARG0000010431512
lims2 / LIM and senescent cell antigen-like domains 2 / LIMS3* / LIMS4* / LIMS1* / P48059* / P0CW19* / P0CW20* / AC013271.1* / AC112229.3* / LIM zinc finger domain containing 3* / LIM zinc ...ENSDARG0000001497612
fhl1b / four and a half LIM domains 1b / FHL1* / Fhl4* / Q13642* / P97447* / four and a half LIM domains 1* / Four and a half LIM domains protein 1 *ENSDARG0000005665311
fhl1a / four and a half LIM domains 1a / FHL1* / Fhl4* / Q13642* / P97447* / four and a half LIM domains 1* / Four and a half LIM domains protein 1 *ENSDARG0000007149810
ldb3b / LIM domain binding 3bENSDARG000000999744


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR001904  Paxillin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0061055 myotome development IGI
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle decreased volume , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000135 notochord notochord malformed , abnormal
Show

 ZFA:0000471 atrium atrium decreased volume , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum decreased amount , abnormal
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 ZFA:0001056 myotome myotome malformed , abnormal
myotome muscle tendon junction decreased amount , abnormal
myotome muscle tendon junction increased amount , abnormal
myotome muscle tendon junction increased distribution , abnormal
myotome muscle cell increased length , abnormal
myotome muscle cell detached from myotome muscle tendon junction, abnormal
Show

 ZFA:0001094 whole organism whole organism absent , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region notochord kinked , abnormal
Show

 ZFA:0005744 notochord outer sheath cell notochord outer sheath cell mislocalised , abnormal
notochord outer sheath cell cytoplasm mislocalised , abnormal
notochord outer sheath cell cell-cell junction mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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